Perioperative administration of cefazolin and metronidazole in obese and non-obese patients: a pharmacokinetic study in plasma and interstitial fluid

C Dorn, D Petroff, M Stoelzel, MG Kees… - Journal of …, 2021 - academic.oup.com
… and subcutaneous tissue of obese patients undergoing bariatric surgery, compared with a
… were distinctly lower in the obese group than in the non-obese group, but decreased more …

Prophylactic cefazolin concentrations in morbidly obese patients undergoing sleeve gastrectomy: do we achieve targets?

M Grégoire, R Dumont, L Ronchi, JB Woillard… - International journal of …, 2018 - Elsevier
… ) (subcutaneous tissue concentration of cefazolin above the … Bariatric surgery is offered to
overweight patients to reduce … Moreover, this model included obese and non-obese patients, …

Lack of pharmacokinetic basis of weight-based dosing and intra-operative re-dosing with cefazolin surgical prophylaxis in obese patients: implications for antibiotic …

S Blum, CB Cunha, BA Cunha - Surgical Infections, 2019 - liebertpub.com
… The optimal IV dose for skin and soft tissue infections in patients with normal renal …
cefazolin concentrations, but significantly lower unbound cefazolin ISF in obese versus non-obese

[HTML][HTML] Cefazolin tissue concentrations with a prophylactic dose administered before sleeve gastrectomy in obese patients: a single centre study in 116 patients

R Cinotti, R Dumont, L Ronchi, A Roquilly… - British Journal of …, 2018 - Elsevier
reduced cefazolin subcutaneous tissue concentrations, data regarding subcutaneous fatty-tissue
concentrations in severely obese … In a retrospective cohort study, obese and non-obese

Efficacious cefazolin prophylactic dose for morbidly obese women undergoing bariatric surgery based on evidence from subcutaneous microdialysis and populational …

EC Palma, NG Meinhardt, AT Stein, I Heineck… - Pharmaceutical …, 2018 - Springer
… Some studies carried out during surgery, however, question the adequacy of this dose in
obese patients since CFZ distribution to subcutaneous tissue is reduced in morbidly obese

[HTML][HTML] Measurement of soft tissue drug concentrations in morbidly obese and non-obese patients–a prospective, parallel group, open-labeled, controlled, phase IV …

P Simon, D Petroff, C Dorn, L Ehmann, C Kloft… - Contemporary Clinical …, 2019 - Elsevier
… /tazobactam, fosfomcyine, cefazolin, metronidazole and as … /m 2 for obese or between 18.5
and 30 kg/m 2 for non-obesecut-off 20,000 Da, CMA, Kista, Sweden) were placed into the …

Plasma and tissue pharmacokinetics of fosfomycin in morbidly obese and non-obese surgical patients: a controlled clinical trial

C Dorn, D Petroff, N Neumann, A Kratzer… - Journal of …, 2019 - academic.oup.com
… of surgical patients were only marginally different between obese and non-obese patients,
the drug exposure in subcutaneous tissue was significantly lower in the obese patients. …

Does current cefazolin dosing achieve adequate tissue and blood concentrations in obese women undergoing cesarean section?

JJF Kram, DM Greer, O Cabrera, R Burlage… - European Journal of …, 2017 - Elsevier
… women are at greater risk for infection than non-obese … Two adipose samples were
collected from subcutaneous tissue, 1 … However, following observation of decreasing cefazolin

Association between pre-operative cefazolin dose and surgical site infection in obese patients

WJ Peppard, DG Eberle, NW Kugler, DM Mabrey… - Surgical …, 2017 - liebertpub.com
… of distribution of cefazolin increases, resulting in a decrease in … of cefazolin commonly
observed among obese patients … concentrations, irrespective of BMI, among morbidly obese

[HTML][HTML] Prophylactic cefazolin dosing and surgical site infections: does the dose matter in obese patients?

Z Hussain, C Curtain, C Mirkazemi, K Gadd… - Obesity surgery, 2019 - Springer
… the recommended dose or weight or BMI cut-off values [6, 7]. … of cefazolin may be inadequate
in morbidly obese patients … SSI prevalence between obese and non-obese patients, or …