Reduction in postpercutaneous coronary intervention angina in addition to gastrointestinal events in patients on combined proton pump inhibitors and dual antiplatelet …

MY Khan, WJ Siddiqui, C Alvarez… - European Journal of …, 2018 - journals.lww.com
Background Primary percutaneous coronary intervention (PCI) is a standard treatment in
patients with acute coronary syndrome. Studies have shown that proton pump inhibitors
(PPIs) can potentially attenuate the antiplatelet effects of P2Y12 inhibitors with associated
adverse cardiovascular outcomes. Materials and methods Medline was searched using
Pubmed from inception to 8 November 2017 for randomized control trials studying the effect
of PPIs on coronary artery disease with concomitant use of dual antiplatelet therapy (DAPT) …
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