[HTML][HTML] Low molecular weight hyaluronan inhibits lung epithelial ion channels by activating the calcium-sensing receptor

A Lazrak, W Song, Z Yu, S Zhang, A Nellore… - Matrix Biology, 2023 - Elsevier
… involvement in the regulation of vectorial ion transport across lung epithelia. … hyaluronan
breakdown to smaller fragments of low molecular weight (<500 kDa) can cause lung injury or …

[PDF][PDF] Hyaluronic acid in inflammation and tissue regeneration

M Litwiniuk, A Krejner, MS Speyrer, AR Gauto, T Grzela - Wounds, 2016 - researchgate.net
Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med. 2005;11…
Interaction of low molecular weight hyaluronan with CD44 and tolllike receptors promotes …

Hyaluronan: a master switch between vascular homeostasis and inflammation

M Grandoch, PL Bollyky, JW Fischer - Circulation Research, 2018 - Am Heart Assoc
… responses and phenotypic control of mesenchymal cells in the … alternative HA receptors,
such as TLR (toll-like receptors), … of tissue damage as shown, for example, in lung injury and …

Use of radiolabeled hyaluronic acid for preclinical assessment of inflammatory injury and acute respiratory distress syndrome

F Zhao, CJ Barber, S Sammani, L Wan… - Nuclear Medicine and …, 2022 - Elsevier
… and oligosaccharides serve as Toll-like receptors (TLRs) … the residual activity of control
lungs. Unlike in the images of … -induced pulmonary injury in this study, the lung parenchyma …

Upregulation of airway smooth muscle calcium-sensing receptor by low-molecular-weight hyaluronan

A Lazrak, Z Yu, S Doran, MY Jian… - … of Physiology-Lung …, 2020 - journals.physiology.org
… accidents leads to acute lung injury and significant increases … Control mice were exposed
to air in the same experimental … via binding to CD44 and Toll-like receptors (TLR) signaling in …

Modified high-molecular-weight hyaluronan promotes allergen-specific immune tolerance

JA Gebe, K Yadava, SM Ruppert… - American Journal of …, 2017 - atsjournals.org
… Many of these proinflammatory effects are attributed to interactions with Toll-like receptor (TLR) …
As a control for HA composition, we evaluated alginate (ALG), a polymer with charge and …

Ozone exposure promotes pyroptosis in rat lungs via the TLR2/4-NF-κB-NLRP3 signaling pathway

L Tian, J Yan, K Li, W Zhang, B Lin, W Lai, L Bian, H Liu… - Toxicology, 2021 - Elsevier
… (HMGB1), hyaluronic acid (HA) and Toll-like receptors 2/4 (… tank in real time and control
the ozone generator to maintain … In conclusion, Ozone exposure can cause lung injury in rats …

TLR2, TLR4, and NLRP3 mediated the balance between host immune-driven resistance and tolerance in Staphylococcus aureus-infected mice

Z Gong, J Zhang, S Zhang, J Cao, Y Fu, X Hu… - Microbial …, 2022 - Elsevier
… with Toll-like receptor 2 (TLR2), TLR4, and Nod-like receptor … protein 1 (HMGB1) and
Hyaluronic acid-binding protein 2 (… TLR2, TLR4 and NLRP3 could regulate the balance between …

[HTML][HTML] Endotoxin free hyaluronan and hyaluronan fragments do not stimulate TNF-α, interleukin-12 or upregulate co-stimulatory molecules in dendritic cells or …

Y Dong, A Arif, M Olsson, V Cali, B Hardman… - Scientific reports, 2016 - nature.com
… white bar) were used as a negative control, along with a FMO control for FL-HA on CD44 +/…
of LPS to induce pro-inflammatory effects through Toll-like receptor 4 (TLR-4), which was also …

[HTML][HTML] Endogenously-produced hyaluronan and its potential to regulate the development of peritoneal adhesions

A Kocurkova, K Nesporova, M Sandanusova… - Biomolecules, 2021 - mdpi.com
… HA fragments are also able to interact with Toll-like receptors, particularly with TLR-2 and
-4, which are responsible for cell activation of pro-inflammatory cytokines and chemokines [36]. …