… for both normal (NL) and cystic fibrosis (CF) airway epithelia … ) metabolism model and a fluid
transport model (collectively … release: cyclic shear stress, cyclic compressive stress, and cilial …

… model of airway surface liquid regulation in normal and CF … is phasic motion during tidal
breathing that imposes stresses … 3 h of CCS-mediated shear stress by increasing the rate of ATP …

… several diseases including cystic fibrosis. With regard to the … With regard to fluid volume
regulation, we discuss the roles of … In addition to phasic shear stress mediated release of ATP, it …

Measurements of airway surface liquid (ASL) on primary airway epithelial cultures (AECs)
grown at air-liquid interface (ALI) identified ASL depletion as a characteristic abnormality in …

… of airway surface liquid mucostasis, chronic inflammation, and eventual respiratory failure. …
are the main determinants of ASL and cellular volume regulation [7, 11]. In CF, deficient or …

… Therefore, the effect of POM-5 on ASL volume regulation was investigated in CF HBEC.
Cells were incubated overnight under oscillatory shear stress that mimics the phasic motion of …

… Airway surface liquid volume regulation. A: diagram of … and 2) shear on airway surfaces due
to phasic airflow (FIGURE 6Ci). … The concentration-dependent shear stress characteristics of …

… the failure to properly regulate mucus concentration, producing … secretion; 3) confocal airway
surface liquid (ASL) height … materials in normal versus cystic fibrosis airway epithelia. Am J …

… The volume of the periciliary layer and mucus hydration is regulated by the transcellular and
… results from mutations in the CFTR gene and leads to cystic fibrosis (CF). More than 90% of …

… This situation is achieved in cystic fibrosis (CF) by virtue of … pathways, produced airway surface
liquid volume hyperabsorption in the … This abnormality is complemented by the regulatory …