… Previous publications focused specifically on the status of acute toxicity testing requirements
and data uses by US regulatory agencies (Strickland et al. Citation2018) or on current …

… prediction models and data sources used in regulatory and/or … limited data to characterize
new chemicals, the US EPA uses … and use of a new chemical. EPI Suite™ provides input …

… as drug safety and toxicity assessments. These technologies … the massive amounts of data
for this regulatory application. For … data-science tools currently in regulatory use by US-FDA, …

… systemic toxicity testing serves as the basis for regulatory … and US EPA’s CCTE. Briefly,
lethal dose, 50 percent L D 50 … the data set with additional toxicity data or use undersampling …

… US regulatory and public health agencies are charged with … animal toxicity testing of human
pharmaceuticals for regulatory … science approach document from Health Canada on the use …

… used as conventional alternative to testing food additives for which the regulations require
toxicity testing data… Authority (EFSA) and the US EPA, who enable the use of in vitro and in …

… US regulations applicable to food colours. Despite the different regulatory frameworks, the
overall approach … The health-based guidance values derived from toxicity data are different for …

… by US residents over the last few decades. The National Center for Health Statistics (NCHS)
has tracked trends in usage of … actions intended to prevent further cases of liver toxicity. For …

… used for scientific purposes and other EU regulations, such as REACH and the Cosmetic
Products Regulation advocate for a change in the way toxicity … , data on acute systemic toxicity …

… fill the data gaps, government and nongovernment regulatory authorities suggest the use of
in … to fill the screening data regarding API environmental toxicity utilizing the US EPA generic …