DAP12 inhibits pulmonary immune responses to Cryptococcus neoformans

LJ Heung, TM Hohl - Infection and immunity, 2016 - Am Soc Microbiol
cells by incubating with rat IgG anti-mouse CD4, CD8, CD19, and Ter119 followed by BioMag
goat anti-rat IgG magnetic beads (Qiagen) and magnetic depletion to remove T and B cells

Pulmonary iron limitation induced by exogenous type I IFN protects mice from Cryptococcus gattii independently of T cells

MJ Davis, S Moyer, ES Hoke, E Sionov… - MBio, 2019 - Am Soc Microbiol
… IMPORTANCE Cryptococcus neoformans and Cryptococcus … (either CD4 or CD8 T cells
could be required, but not … , would render the host resistant to cryptococcal infection by either …

Basic principles of the virulence of Cryptococcus

O Zaragoza - Virulence, 2019 - Taylor & Francis
… virulence have focused on Cryptococcus neoformans, and for … patients, in particular those
defective in CD4 T cells, C. … of cryptococcal cells in macrophages, so more work is required to …

Cryptococcus neoformans Cda1 and its chitin deacetylase activity are required for fungal pathogenesis

R Upadhya, LG Baker, WC Lam, CA Specht, MJ Donlin… - MBio, 2018 - Am Soc Microbiol
… Chitin is an essential component of the cell wall of Cryptococcus neoformans conferring …
neoformans Cda2 (initially named MP98) was shown to be a potent stimulator of CD4 T cells

Vaccination with a ZNF2oe Strain of Cryptococcus Provides Long-Lasting Protection against Cryptococcosis and Is Effective in Immunocompromised Hosts

T Pham, Y Li, W Watford, X Lin - Infection and Immunity, 2023 - Am Soc Microbiol
… environmental fungus Cryptococcus neoformans is universal. … low CD4 + T cell count, we
tested whether vaccinating hosts … and sterylglucoside are required for host protection in an …

Immunomodulatory Role of Capsular Polysaccharides Constituents of Cryptococcus neoformans

D Decote-Ricardo, IF LaRocque-de-Freitas… - Frontiers in …, 2019 - frontiersin.org
… In some severe cases, medications such as corticosteroids are required to suppress … In
addition, both dendritic cells and CD4+ T cells were detected in bronchoalveolar infiltrate …

The formation of titan cells in Cryptococcus neoformans depends on the mouse strain and correlates with induction of Th2‐type responses

…, C Rueda, B de Andrés… - Cellular …, 2016 - Wiley Online Library
… compared with other elements of the immune response, such as CD4 and CD8 T cells. In …
Although IgM Abs could play a role in the defence against C. neoformans in these mice, this …

Monocytes and the host response to fungal pathogens

LJ Heung - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
… during Cryptococcus neoformans infection can either be detrimental or beneficial to host
macrophages to promote CD8 + T cell cytotoxic responses under conditions where CD4 + T

Use of Clinical Isolates to Establish Criteria for a Mouse Model of Latent Cryptococcus neoformans Infection

M Ding, KD Smith, DL Wiesner, JN Nielsen… - Frontiers in Cellular …, 2022 - frontiersin.org
… In this study, we defined criteria required for latency in C. neoformans infection models and
… EasySep™ Mouse CD4+ T Cell Isolation Kit (19852, StemCell) from single cell suspension of …

Phenotypic Variability Correlates with Clinical Outcome in Cryptococcus Isolates Obtained from Botswanan HIV/AIDS Patients

KE Fernandes, A Brockway, M Haverkamp, CA Cuomo… - MBio, 2018 - Am Soc Microbiol
… isolates of Cryptococcus neoformans and Cryptococcus tetragattii from … In the current study,
CD4 counts ranged from 2 to 389 (Table … is required to substantiate this preliminary finding. …