Ischemia and reperfusion injury combined with cisplatin induces immunogenic cell death in lung cancer cells

S Zhang, Y Li, S Liu, P Ma, M Guo, E Zhou… - Cell Death & …, 2022 - nature.com
… Further studies demonstrated that CDDP cannot induce endoplasmic reticulum (ER) stress
and … Our study presents a new strategy to restore the immunogenicity of CDDP and activate …

Tannins in Phyllanthus emblica L. improves cisplatin efficacy in lung cancer cells by boosting endoplasmic reticulum stress to trigger immunogenic cell death

Q Hu, S Wang, R Cheng, Y Liu, Z Chang, Y Huang… - Phytomedicine, 2024 - Elsevier
… The release of DAMPs is vital in dictating the immunogenicity of tumor cell death. In … me"
signal, exposed on the cell surface, enhancing phagocytes to engulf dead cells. The release of …

Restoration and enhancement of immunogenic cell death of cisplatin by coadministration with digoxin and conjugation to HPMA copolymer

Y Xiang, L Chen, L Li, Y Huang - ACS applied materials & …, 2019 - ACS Publications
… copolymer with subcellular organelles including endoplasmic reticulum, mitochondria, and
… effects on restoration and enhancement of cisplatin-induced immunogenic cell death, which …

[HTML][HTML] Combining cisplatin with Pinellia pedatisecta Schott lipid-soluble extract induces tumor immunogenic cell death in cervical cancer

C Wang, M Zhang, J Peng, M Zhang, C Lu, X Qi, Q Luo… - Phytomedicine, 2024 - Elsevier
endoplasmic reticulum to the cell membrane of tumor cells, concomitantly triggering immunogenic
cell death (… In terms of mechanisms, endoplasmic reticulum (ER) stress relievers could …

Brentuximab Vedotin–Driven Microtubule Disruption Results in Endoplasmic Reticulum Stress Leading to Immunogenic Cell Death and Antitumor Immunity

RA Heiser, AT Cao, W Zeng, M Ulrich, P Younan… - Molecular Cancer …, 2024 - AACR
endoplasmic reticulum (ER) stress response that culminates in the induction of the classic
hallmarks of immunogenic cell death (… lymphoma cells drove innate immune cell activation in …

Necroptosis-dependent immunogenicity of cisplatin: implications for enhancing the radiation-induced abscopal effect

R Luo, K Onyshchenko, L Wang, S Gaedicke… - Clinical Cancer …, 2023 - AACR
… Cisplatin has been shown to induce necroptosis in tumor cells in vitro (33). However, the
importance of necroptosis for the immunogenicity of cisplatin-induced tumor cell death is only …

[HTML][HTML] Immunogenic effects of chemotherapy-induced tumor cell death

YJ Wang, R Fletcher, J Yu, L Zhang - Genes & diseases, 2018 - Elsevier
… chemotherapeutics often involves endoplasmic reticulum (ER… attributed to tumor cell toxicity,
but also the restoration of … can elicit the immunogenicity of tumor cells and modulate the …

Stress-induced cellular responses in immunogenic cell death: Implications for cancer immunotherapy

F Radogna, M Diederich - Biochemical pharmacology, 2018 - Elsevier
… to restore immunogenicity [27]. In a similar manner, mouse … II immunogenic cell death (ICD)
inducers. Type ICD I inducers stimulate non-associated targets of endoplasmic reticulum (ER…

Immunogenic apoptotic cell death and anticancer immunity

P Vandenabeele, K Vandecasteele, C Bachert… - Apoptosis in Cancer …, 2016 - Springer
… Notably, the immunogenicity of drugs such as cisplatin could be restored by combining it
with thapsigargin or tunicamycin [26] or by expression of the ER resident protein reticulon-1 [27]…

eIF2α phosphorylation is pathognomonic for immunogenic cell death

L Bezu, A Sauvat, J Humeau… - Cell Death & …, 2018 - nature.com
… The phosphorylation of eIF2α is essential for the endoplasmic reticulum (ER) stress …
chemotherapeutics have the property to induce immunogenic cell death (ICD), thereby causing …