… rare neuro-metabolic disorder Rett syndrome (RTT) is discussed as a prototype for precision
medicine, demonstrating how mouse models … reversal may be possible in human patients. …

… to female MeCP2+/− mice. This mouse model fully recapitulates symptoms of Rett syndrome
and is widely used in the literature to study the mechanisms underlying this disease.In …

… cause Rett syndrome, a progressive neurological disorder in … At present there are no effective
treatments for Rett syndrome, … Here we find, using a mouse model of Rett syndrome, that …

… study Rett syndrome use mice as a model of the disorder. In particular, male mice with the
mouse … inhibitory activity alone can reverse the majority of symptoms of a mouse model of RTT. …

… expression and/or TrkB activation in Mecp2-deficient mouse models of RTT can ameliorate
or reverse abnormal neurological phenotypes that mimic human RTT symptoms. The present …

… Reversal of respiratory symptoms following mPFC activation was associated with … Thus,
despite reduced levels of MeCP2 and severe neurological deficits, mPFC circuits in Het mice are …

… Promisingly, supplementation of choline, a common dietary micronutrient, to various mouse
models of RTT markedly improved their motoric function [18, 19]. But, the exact mechanism …

… Rett syndrome (RTT) is a neurodevelopmental disorder … , we created and characterized a
mouse model with the common p.… Mecp2 R294X mice exhibit phenotypic abnormalities similar …

… Tubastatin A treatment on reversing early RTT-related abnormalities was therefore investigated
in a Mecp2 308/y mouse model. In this preclinical study, we identified in mice a safe and …

… mouse alleles are the primary models for Rett syndrome (table 3). The Bird laboratory developed
a Mecp2 mutant mouse model … of MeCP2 expression reversed symptoms: neurological …