Evidence on cellular/molecular mechanisms leading to atrial fibrillation (AF) are scanty.
Increased expression of Rho kinase (ROCK) and myosin-phosphatase-target subunit-1
(MYPT-1), ROCK activity's marker, were shown in AF patients, which correlated with
connexin 40 (Cx40) expression, membrane protein of heart gap junctions, key for rapid
action potential's cell–cell transfer. AF is the most frequent arrhythmia in dialysis patients
who present increased MYPT-1 phosphorylation, which correlates with left ventricular (LV) …

Objective: Evidence on cellular and molecular mechanisms that lead to atrial fibrillation (AF)
are scanty. Increased expression of ROCK and myosin phosphatase target subunit 1 (MYPT-
1), involved in ROCK signaling were shown in left atrial appendage biopsies of AF patients,
which correlated with the expression of Connexin40 (Cx40), an integral membrane protein
of heart gap junctions, fundamental for the rapid cell-cell transfer of action potential. AF is the
most frequent cardiac arrhythmia in dialysis patients who, we demonstrated to present …