… Thus, the RhoA/Rho-kinase pathway plays crucial roles … pathological conditions and is an
important therapeutic target in … of Rho-kinase for the treatment of cardiovascular disease have …

… of cardiac remodeling. … therapeutic targets for cardiovascular diseases. In this review,
we summarize the current understanding of the roles of ROCKs in the development of cardiac …

… calcineurin and Rho kinase activity, respectively. In this review, the regulation and the function
of RCAN1 are summarized. Moreover, the dysregulation of RCAN1 in CVDs is reviewed. …

… treatment of many diseases such as cancer or multiple sclerosis, and especially for the
treatment of cardiovascular diseases… 41 chemical compounds as Rho kinase inhibitors based on …

… pathogenesis of cardiovascular diseases. The activation of RhoA/Rho kinase pathway acts
… clinical effects as a therapeutic target in a variety of human diseases including, in particular, …

… These data suggest the ROCK inhibitor is a potential therapeutic target for many diseases
resulting from abnormally high smooth muscle contraction. Since the introduction of this work, …

… cardiac disorders treatment. The emphasis of this review will be on bringing recent development
in cardiac disorders from the discoveries of drug targets … inhibition of Rho kinases [102]. …

… microbleeds may stem from cardiovascular disorders, of which hypertension and
hypercholesterolemia are recognized vascular risk factors for AD (Santos et al. 2017). The idea that …

… The effects of fasudil on endothelial function in atherosclerosis is tested in patients with
coronary artery disease (CAD). These results suggest that activation of Rho kinase (ROCK) …

… vascular nerves and blood pressure regulation. In this sense, MLCK appears to be an attractive
therapeutic target for cardiac diseases. … signal from Rho/Rho kinase and phosphorylates …