A systematic review on rho-kinase as a potential therapeutic target for the treatment of erectile dysfunction

KA Zewdie, MA Ayza, BA Tesfaye… - … and Reports in …, 2020 - Taylor & Francis
… (ICP/MAP) was decreased due to age and various chronic … Rho-associated coil-forming
protein kinase (ROCK) is … , atherosclerosis, and pelvic irradiation) and medication side effects …

Cardiac aging: from basic research to therapeutics

M Yan, S Sun, K Xu, X Huang, L Dou… - … and cellular …, 2021 - Wiley Online Library
… The deletion of Rho-associated coiled-coil-containing protein kinase (ROCK)1 … atherosclerosis
[95, 96]. mTOR inhibition triggers autophagy, promotes cell survival and cholesterol efflux, …

Attenuation of obesity-induced insulin resistance in mice with heterozygous deletion of ROCK2

H Soliman, JN Varela, V Nyamandi… - International journal of …, 2016 - nature.com
Rho-associated coiled-coil-containing kinase 2 deficiency in bone marrow-derived cells
leads to increased cholesterol efflux and decreased atherosclerosis. Circulation 2012; 126: 2236…

[HTML][HTML] Data on gene and protein expression changes induced by apabetalone (RVX-208) in ex vivo treated human whole blood and primary hepatocytes

S Wasiak, D Gilham, LM Tsujikawa, C Halliday… - Data in brief, 2016 - Elsevier
… published in Atherosclerosis “RVX-208, a BET-inhibitor for Treating … T-cells; VSMC:
vascular smooth muscle cells; Italics indicates literature support for both pro-and anti-atherosclerotic

Discovery of novel highly selective Rho kinase (ROCK) inhibitory peptides and evaluation of their biological activities

R Abbasgholizadeh - 2017 - uh-ir.tdl.org
Rho-associated kinases (ROCKs), a member of the AGC … to atherosclerosis pathogenesis.
Deletion of ROCK1 or ROCK2 in bone marrowderived cells decreased inflammatory cells (…

Programmed cell death and lipid metabolism of macrophages in NAFLD

Z Xiao, M Liu, F Yang, G Liu, J Liu, W Zhao… - Frontiers in …, 2023 - frontiersin.org
… that aging led to increased necroptosis in liver macrophages and … via Rho-associated
coiled-coil-containing protein kinase (… An atherosclerosis-based study found that MLKL deficiency

Milk's role as an epigenetic regulator in health and disease

BC Melnik, G Schmitz - Diseases, 2017 - mdpi.com
… CPT1A, thus attenuates cholesterol efflux, hepatic LDL uptake, … Rho-associated coiled-coil
containing protein kinase 1 (… differentiation of human bone marrow-derived stem cells [267]. …

Efferocytosis in dendritic cells: an overlooked immunoregulatory process

Y Ma, T Jiang, X Zhu, Y Xu, K Wan, T Zhang… - Frontiers in …, 2024 - frontiersin.org
kinase activity of the Rho-associated coiled-coil-containing … , which promotes cholesterol
efflux within the cell, plays a … /Rac1 signaling and reduces atherosclerotic lesion necrosis. J …

Correlation of age of onset and clinical severity in Niemann–Pick disease type C1 with lysosomal abnormalities and gene expression

LL Baxter, DE Watkins-Chow, NL Johnson, NY Farhat… - Scientific reports, 2022 - nature.com
… , which are frequently identified due to increased clumsiness and learning … cell lines into
two groups (Fig. 4, Branches A and B) and genes into two groups with relatively high or low

[PDF][PDF] COMBATING DIABETES AND DIABETIC KIDNEY DISEASE

SP Srivastava, J Goodwin, K Kanasaki - researchgate.net
… First, we discuss new leads targeted to DKD. In recent years … endothelial cells and its
deficiency influences cellular trans-… that LPS decreased the expression of LC3II and beclin-1, but …