Background Rhodiola rosea (R. rosea) is a botanical adaptogen with putative anti-stress
and antidepressant properties. Evidence-based data supporting the effectiveness of R.
rosea for depression in adults is limited, and therefore a comprehensive review of available
animal and human studies suggesting a putative antidepressant action is warranted.
Purpose A review of the literature was undertaken to ascertain studies of possible
antidepressant mechanisms of action and studies of the safety and effectiveness of R. rosea …