… the role of Ca 2+ transport systems at the ER and mitochondria … modulate apoptosis onset
by targeting the Ca 2+ machinery. … of truncated SERCA1 isoform predisposes to ER stress and …

… Calcium signaling plays an important role in cell survival by influencing … Ca 2 + homeostasis
and promote apoptosis is related to the induction S1T, the truncated isoform of SERCA1, as …

… by suppressing pro-apoptotic ER-mitochondrial Ca 2+ transfer, while … Aside from functional
SERCA pumps, a truncated SERCA1 (S1T) … This study on SERCA1 was preceded by a study …

… to apoptosis through the control of Ca 2+ mobilization from ER to mitochondria [14]. … We
also revealed that full-length SERCA1 isoform appeared poorly expressed in both control and …

… transfer of Ca 2+ can occur from the ER to the mitochondrial … other hand triggering ER
stress and/or apoptosis. Regulation … Each of the three IP 3 R isoforms form large homo- or …

… of cell fate via apoptosis and cell growth. On the other hand, … sequence that results in a novel,
truncated C-terminus. It is tempting … and ubiquitous SERCA isoforms (SERCA1 & SERCA2), …

… , VDAC1, SERCA3, and SERCA1. Later on we confirmed it by … in three isoforms: full-length
PR-B, N-terminally truncated PR-… play a key role in mitochondria-mediated apoptosis and are …

… to the endoplasmic reticulum (ER), the major calcium (Ca 2 + … is transferred to mitochondria
through the mitochondrial Ca 2 … the function of the main players of the ER mitochondrial Ca 2 …

… there is a truncated but functional form of type 1 RyR [[21]]. The … There are three isoforms of
SERCA (SERCA 1-3), each of … 2+ into the mitochondria from the ER and induce apoptosis in …

… to contribute to podocyte apoptosis by facilitating mitochondrial Ca 2+ … mitochondria-associated
membrane’s role, particularly the IP 3 R-Grp75-VDAC1 pathway, in calcium ion transport …