… corneal epithelial barrier function in DED and that Th17 cells, together with Th1 and Th2 cell,
are … The key role of CD4 + T cells in DED pathogenesis is also corroborated by interesting …

… pathogenesis of dry eye among these conditions. While the specific role of MMPs in accelerated
corneal endothelial cell … pathophysiological mechanisms in dry eye remains unknown, …

… dry eye disease pathogenesis. IL-1, IL-6 and TNF-α have been suggested to play a role in
destruction of acinar cells … naïve T cells and initiate their differentiation to Th1 and Th17 cells, …

… The proportion of Th-17 cell in tears of diabetic dry eye group was significantly higher than
that … and Th-17 cells may play a key role in the pathogenesis of diabetic patients with dry eye. …

… an important role in the pathogenesis of ocular surface disease, including dry eye disease
(DED… increased frequencies of Th17 cells and overexpression of Th17-associated cytokines in …

… γ released by Th1 cells causes epithelial cell apoptosis, squamous … cells, 9 – 11 and IL-17
released by Th17 cells causes corneal barrier dysfunction. Although the immunopathogenesis …

… Th-17 axis, which involves the cytokines IL-17, IL-22 and IL-23, plays a crucial role in the
pathogenesis … the fact that Th-17 cells are involved in systemic inflammatory diseases such as …

… of both aqueous deficiency and evaporative dry eye must be performed. Table 1 summarizes
the main clinical tests performed on patients with dry eye symptoms. Patients should be …

… lesion due to dry eye syndrome, aggravating … Th17 cells as CD161 + RORγt + cells and
they did not examine the levels of IL-17A. When we defined Th17 cells as CXCR3 − CCR6 + cells…

… Ocular surface diseases (OSDs) are a group … functions; this can cause functional impairment
and lead to vision loss. Common disorders affecting the ocular surface are dry eye disease (…