[HTML][HTML] VEGF-A and blood vessels: a beta cell perspective

W Staels, Y Heremans, H Heimberg, N De Leu - Diabetologia, 2019 - Springer
… of the role of vascular endothelial growth factor-A (VEGF-A) and endothelial cells in beta cell
… In addition, the therapeutic potential of modulating VEGF-A levels in beta and beta-like cells

INGAP-PP effects on β-cell mass and function are related to its positive effect on islet angiogenesis and VEGFA production

CL Román, B Maiztegui, H Del Zotto… - Molecular and Cellular …, 2018 - Elsevier
… and promoted islet angiogenesis and VEGF-A production/release. We also showed that
VEGF-A potentiated the positive effect of INGAP-PP on β-cells, probably through mTORC …

[PDF][PDF] The role of mesenchymal stem cells in regulating PDGF and VEGF during pancreatic islet cells regeneration in diabetic animal model

A Putra, ZH Suwiryo, AM Muhar, A Widyatmoko… - Folia medica, 2021 - foliamedica.bg
… of pancreatic cells, particularly β-cell and endothelial cells.… can cause a deleterious effect
on an islet cell function in… and PDGF play a major role in pancreatic β-cells regeneration, the …

[HTML][HTML] VEGF-B ablation in pancreatic β-cells upregulates insulin expression without affecting glucose homeostasis or islet lipid uptake

FC Ning, N Jensen, J Mi, W Lindström, M Balan… - Scientific Reports, 2020 - nature.com
… The biological function of VEGF-B has long been poorly understood. Despite its
sequence homology with VEGF-A 21 , its role in angiogenesis is limited to conditions of over-expression …

Placental growth factor in beta cells plays an essential role in gestational beta-cell growth

W Yang, Y Jiang, Y Wang, T Zhang, Q Liu… - BMJ Open Diabetes …, 2020 - drc.bmj.com
… Since beta cells produce both VEGF-A and PlGF, we then examined expression of both VEGF-A
and PlGF in beta cells in … Interestingly, we found that VEGF-A levels in beta cells remain …

[HTML][HTML] The role of vascular cells in pancreatic beta-cell function

G Burganova, C Bridges, P Thorn… - Frontiers in …, 2021 - frontiersin.org
… the vascular cells and β-cells and its role in glucose homeostasis and diabetes. … cells and
neurons (1–4). This review focuses on the crosstalk of β-cells with vascular cells and their role

[HTML][HTML] Vegfa/vegfr2 signaling is necessary for zebrafish islet vessel development, but is dispensable for beta-cell and alpha-cell formation

CM Toselli, BM Wilkinson, J Paterson, TJ Kieffer - Scientific reports, 2019 - nature.com
… if beta-cells originating from the dorsal and ventral pancreaticcell assay to mark dorsal
pancreatic bud derived beta-cells 14 . In this assay, H2B-EBFP mRNA is injected into one cell

[HTML][HTML] Vegf-A mRNA transfection as a novel approach to improve mouse and human islet graft revascularisation

W Staels, Y Verdonck, Y Heremans, G Leuckx… - Diabetologia, 2018 - Springer
… The potential of Vegf-A mRNA transfection was further evaluated in the human pancreatic
beta cell line EndoC-bH3 and in primary human islet grafts (the experimental designs are …

Signals in the pancreatic islet microenvironment influence βcell proliferation

KI Aamodt, AC Powers - Diabetes, Obesity and Metabolism, 2017 - Wiley Online Library
… and endocrine pancreas. In addition to regulating development of the pancreatic epithelium,
VEGF-A is … , innervation and function15, 16, 18, 65, 70-74 After development, the endocrine …

Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling

Y Xiong, MJ Scerbo, A Seelig, F Volta, N O'Brien… - Elife, 2020 - elifesciences.org
… Impaired insulin secretion in vivo but enhanced insulin secretion from isolated islets in
pancreatic beta cell-specific vascular endothelial growth factor-A knock-out mice. Diabetologia 50:…