… For example, overexpression of VEGF-A in the developing pancreas leads to a
hypervascularized pancreas and ectopic insulin expression [12]. Consistently, knock-out of the anti-…

… starting one day before VEGF-A induction and continuing for 1 week after VEGF-A normalization
(Fig. 2a). … , NF-kB nuclear factor kappa-light-chain-enhancer of activated B cells, PI3K …

… The aim of the present study was to investigate the role of the PKCβII/HuR/VEGF-A pathway
in the development of DR using the Ins2 Akita mouse animal model, which is characterized …

… numerous cell types, including vascular-associated pericytes and macrophages. In the islet,
… beta cell is a major source of VEGF production. Indeed, beta cell-specific deletion of VEGF-A …

… This study showed that the atRA-induced upregulation of VEGF-A produced by the islets
mediated the restoration of islet vascularity and recovery of β−cell mass. Combination of islet …

… of insulin–PI3K signalling in endothelial cells on pancreatic beta cells. We investigated the
… in pancreatic beta cells led to reduced beta cell mass and function in VE-PDPK1-KO mice. …

… Inactivation of VEGF-A during adulthood causes reduced islet vascularization; … β-cell mass
and function were preserved, suggesting that VEGF-A has a lesser role in adult β-cell function …

… In the present study, we determined the role of VEGF in the aerobic glycolysis of pancreatic
cancer. We provided evidence that VEGF causes a metabolic transition from mitochondrial …

… VEGF-A induces the formation of both new vessels and their fenestrae on the surface of
endothelial cells. HGF released from the endothelial maintain both glucose-stimulated insulin …

… between intra-islet endothelial cells and beta cells. The molecules involved in the …
pancreas; increased levels of VEGF-A correspond with islet growth in pregnant rats[47]. VEGF-A …