Non-canonical roles of connexins

R Van Campenhout, A Cooreman, K Leroy… - Progress in biophysics …, 2020 - Elsevier
… The role of connexin proteins in the control of homeostasis remains to be elucidated. It has
been suggested that specific parts of connexin proteins directly affect gene transcription. Thus…

Connexin's connection in breast cancer growth and progression

D Banerjee - International journal of cell biology, 2016 - Wiley Online Library
… The expression, localization, and channel formation of all these connexins are distinct and
controlled in a precise manner throughout the mammary gland development. Cx26 is the first …

Connexin and gap junctions: perspectives from biology to nanotechnology based therapeutics

S Jindal, S Chockalingam, SS Ghosh… - Translational …, 2021 - Elsevier
… One way by which connexins regulate biological processes is by controlling the gap junction
mediated intercellular transfer of second messengers. Thus functional assays which can …

Inner ear connexin channels: roles in development and maintenance of cochlear function

F Mammano - Cold Spring Harbor perspectives …, 2019 - perspectivesinmedicine.cshlp.org
connexin genes are expressed both in humans (identified by a “GJ” prefix) and in mice (identified
by a “Gj” prefix) (Table 1). Note that two connexins … factors that control the opening and …

The role of connexins during early embryonic development: pluripotent stem cells, gene editing, and artificial embryonic tissues as tools to close the knowledge gap

P Wörsdörfer, N Wagner, S Ergün - Histochemistry and Cell Biology, 2018 - Springer
… of connexins in the context of human development and even in cells directly derived from
patients affected by mutated connexin genes. … connexins in PSCs and their role in controlling

Connexin communication compartments and wound repair in epithelial tissue

M Chanson, M Watanabe, EM O'Shaughnessy… - International journal of …, 2018 - mdpi.com
… of connexin genes in zebrafish compared with that in humans is due to gene duplication …
Independent of evx1 function, Cx43 controls the switching of fin growth and joint formation …

Connexins: key players in the control of vascular plasticity and function

U Pohl - Physiological reviews, 2020 - journals.physiology.org
… -independent roles of connexins in blood vessel functionconnexin functions constitute
an often underestimated basis for the enormous plasticity of vascular morphology and function

[HTML][HTML] The connexin 43 C-terminus: A tail of many tales

E Leithe, M Mesnil, T Aasen - Biochimica et Biophysica Acta (BBA) …, 2018 - Elsevier
… has important roles in controlling cell growth and differentiation … connexin functions unrelated
to GJIC have been discovered. Of the 21 members of the human connexin family, connexin

Regulation of connexin signaling by the epigenetic machinery

M Vinken - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2016 - Elsevier
connexin production is equally dictated by epigenetic actions. This paper provides an overview
of the role … of tissue-specific transcription factors control connexin gene transcription, like …

Antagonistic functions of connexin 43 during the development of primary or secondary bone tumors

J Talbot, M Dupuy, S Morice, F Rédini, F Verrecchia - Biomolecules, 2020 - mdpi.com
… tumor growth [67]. The hypothesis of the main role of Gj in the control of tumor growth by …
cell proliferation and primary tumor growth [69,70]. One of the mechanisms that explains the …