… -limited media and a defect in transporting the Cfo1 ferroxidase of the high-affinity iron
uptake system from the plasma membrane to the vacuole. Remarkably, we made the novel …

… of a low-affinity iron uptake system, but the underlying … High-affinity iron uptake involves the
ferroxidase Cfo1 and … and host iron (eg transferrin) iron sources, as well as for virulence and …

… that Atm1 plays a critical role in iron metabolism and virulence for C. neoformans. … In the
current study, we observed that the transcript levels for genes involved in iron uptake, such as …

… to virulence of reductive iron uptake, siderophore-mediated … : Candida albicans, Cryptococcus
neoformans and Aspergillus … transport complex consisting of the multicopper ferroxidase …

… the ferric reductases and is a cell surface ferroxidase belonging … such as Candida albicans,
Cryptococcus neoformans, and … Although iron metabolism and its role in the virulence of the …

… in the host but also in the expression of major virulence … affinity reductive iron uptake system
is known to play a role in … lacking the CFO1 (ferroxidase) and CFT1 (iron permease) genes …

… , the gene encoding a ferroxidase for high-affinity iron transport at the plasma membrane [12]. …
that Lys4 function may be associated with iron metabolism in C. neoformans. The fact that …

… subsequent transport by a permease (Cft1) and ferroxidase (… The expression of these and
other iron-related functions in C… iron sensing and the regulation of iron uptake functions with …

… Iron is an essential metal required for several enzymatic and … a crucial role in the virulence
of microbial pathogens including C. … pathways in heme-iron uptake and metabolism and their …

… uptake and attenuated virulence in mice (26, 35). The combination of pharmacological and
genetic approaches supports a role for endocytosis in heme uptake… by regulating iron uptake …