Disorders affecting the sperm, oocyte, or embryo may cause a significant fraction of
spontaneous miscarriages and cases of recurrent pregnancy loss (RPL). Altered
chromosomal integrity of sperm and oocytes, which is highly dependent of the age of the
mother, represents a major cause of miscarriage and in turn RPL. Avoiding transfers of
abnormal embryos is possible with preimplantation genetic testing for aneuploidies.
Chromosomal anomalies may also be caused by structural rearrangements of one or …