Safety and immunogenicity of a novel multivalent OspA-based vaccine candidate against Lyme borreliosis: a randomised, phase 1 study in healthy adults
N Bézay, R Hochreiter, V Kadlecek… - The Lancet Infectious …, 2023 - thelancet.com
… a novel Lyme borreliosis vaccine candidate (VLA15) targeting the six most common outer
surface protein A (OspA) … a multivalent Lyme borreliosis vaccine candidate that was safe and …
surface protein A (OspA) … a multivalent Lyme borreliosis vaccine candidate that was safe and …
Broadly protective multivalent OspA vaccine against Lyme borreliosis, developed based on surface shaping of the C-terminal fragment
A Nayak, W Schüler, S Seidel, I Gomez… - Infection and …, 2020 - Am Soc Microbiol
… afzelii OspA ST2, the most important Borrelia species … that the novel multivalent OspA-based
vaccine approach has the … of the linker sequence to immunogenicity and protection was …
vaccine approach has the … of the linker sequence to immunogenicity and protection was …
Safety, immunogenicity, and efficacy of Borrelia burgdorferi outer surface protein A (OspA) vaccine: A meta-analysis
H Zhao, FF Bao, A Liu - The Journal of Infection in Developing Countries, 2017 - jidc.org
… Conclusions: The OspA vaccine against Lyme disease is safe and its immunogenicity and
… on a newgeneration, multivalent OspA-based Lyme borreliosis vaccine intended to protect …
… on a newgeneration, multivalent OspA-based Lyme borreliosis vaccine intended to protect …
Single-domain antibodies reveal unique borrelicidal epitopes on the Lyme disease vaccine antigen, outer surface protein A (OspA)
DJ Vance, S Basir, CL Piazza, GG Willsey… - Infection and …, 2024 - Am Soc Microbiol
… The V H Hs displayed unique reactivity profiles with the seven OspA … OspA serotypes that
should be considered when designing and evaluating multivalent Lyme disease vaccines. …
should be considered when designing and evaluating multivalent Lyme disease vaccines. …
The novel Lyme borreliosis vaccine VLA15 shows broad protection against Borrelia species expressing six different OspA serotypes
P Comstedt, W Schüler, A Meinke, U Lundberg - PloS one, 2017 - journals.plos.org
… In order to improve the OspA ST3 specific immunogenicity as well as the yield of the fusion
… Subsequently, immune sera obtained from the clinical trial with the multivalent OspA vaccine …
… Subsequently, immune sera obtained from the clinical trial with the multivalent OspA vaccine …
Design of a broadly reactive Lyme disease vaccine
HD Kamp, KA Swanson, RR Wei, PK Dhal… - npj Vaccines, 2020 - nature.com
… Nanoparticle delivery of the OspA antigen is a novel vaccine approach to Lyme disease. We
… , OspA, in its natural conformation in an ordered multivalent array to improve immunogenicity…
… , OspA, in its natural conformation in an ordered multivalent array to improve immunogenicity…
The year that shaped the outcome of the OspA vaccine for human Lyme disease
RJ Dattwyler, M Gomes-Solecki - Npj Vaccines, 2022 - nature.com
… the current modifications of recombinant OspA to develop a multivalent subunit vaccine for
Lyme … The safety and immunogenicity of the rOspA vaccine was again tested in 30 healthy …
Lyme … The safety and immunogenicity of the rOspA vaccine was again tested in 30 healthy …
A systematic review and meta-analysis for the adverse effects, immunogenicity and efficacy of Lyme disease vaccines: Guiding novel vaccine development
A Badawi, M Shering, S Rahman… - Canadian Journal of Public …, 2017 - Springer
… the monovalent and multivalent LB vaccines result in mild … multivalent vaccine slightly more
tolerable than the monovalent one. Both vaccine classes were similarly highly immunogenic. …
tolerable than the monovalent one. Both vaccine classes were similarly highly immunogenic. …
Human B cell epitope map of the lyme disease vaccine antigen, OspA
… serum antibody titers against a single epitope near the C-terminus of OspA, as … OspA following
vaccination remains undefined even as next-generation multivalent OspA-based vaccines …
vaccination remains undefined even as next-generation multivalent OspA-based vaccines …
Antigen engineering approaches for Lyme disease vaccines
… Lyme disease vaccine based on lipidated recombinant OspA, … Multivalent approaches in
Lyme disease vaccines have … Immunogenicity of Lyme disease vaccinogens can potentially be …
Lyme disease vaccines have … Immunogenicity of Lyme disease vaccinogens can potentially be …