Capsaicin and its role in chronic diseases

ES Fernandes, ARA Cerqueira, AG Soares… - Drug Discovery from …, 2016 - Springer
… transient receptor potential vanilloid 1 (TRPV1), capsaicin and … cells with capsazepine, a
non-selective TRPV1 antagonist, … to summarize evidences related to the effects of capsaicin on …

cAMP signaling through protein kinase A and Epac2 induces substance P release in the rat spinal cord

W Chen, JA McRoberts, HS Ennes, JC Marvizon - Neuropharmacology, 2021 - Elsevier
… Second, we studied whether NMDA receptor antagonists … However, ifenprodil, a selective
antagonist of NR2B subunit-… (“none”) or with the TRPV1 antagonists capsazepine (100 μM) or …

Antioxidative and analgesic effects of naringin through selective inhibition of transient receptor potential vanilloid member 1

S Eom, BB Lee, S Lee, Y Park, HD Yeom, TH Kim… - Antioxidants, 2021 - mdpi.com
capsazepine, an approved TRPV1 antagonist. The half-maximal inhibitory concentration (IC50)
values of naringin and capsazepine … that naringin selectively inhibited capsaicin-evoked …

[HTML][HTML] Inhibitive effect of loureirin B plus capsaicin on tetrodotoxin-resistant sodium channel

C Su, W Ying, L Xiangming, P Xinxin - Journal of Traditional Chinese …, 2018 - Elsevier
… by pretreatment with TRPV1 antagonist capsazepine. In … Capsazepine, the competitive
antagonist of TRPV1 receptor, … There was evidence that, non-selective effects of capsaicin on …

Capsaicin-sensitive sensory nerves and the TRPV1 ion channel in cardiac physiology and pathologies

T Szabados, K Gömöri, L Pálvölgyi, A Görbe… - International journal of …, 2020 - mdpi.com
… functional evidence indicate that capsaicin-sensitive primary afferent neurons of both spinal
… mediated by TRPV1 receptors since TRPV1 receptor antagonists (capsazepine or P5, a …

Inhibition of transient receptor potential vanilloid type 1 through α2 adrenergic receptors at peripheral nerve terminals relieves pain

Y Matsushita, M Manabe, I Kitagawa… - Journal of Veterinary …, 2021 - jstage.jst.go.jp
… a more specific TRPV1 antagonist than capsazepine in this … of capsazepine and JNJ-17203212
on capsaicin currents and … rat spinal cord and antagonism by alpha-adrenergic receptor

Supraspinal-selective TRPV1 desensitization induced by intracerebroventricular treatment with resiniferatoxin

A Fukushima, K Mamada, A Iimura, H Ono - Scientific reports, 2017 - nature.com
… of capsazepine, a competitive TRPV1 antagonist, and TRPV1 … ) are effective in the capsaicin
test 31,35 , the effectiveness of … The results of the present study provide additional evidence

TRPV1 agonist, capsaicin, induces axon outgrowth after injury via Ca2+/PKA signaling

E Frey, S Karney-Grobe, T Krolak, J Milbrandt… - eneuro, 2018 - eneuro.org
… it may be possible to target selective neuronal populations for repair, … We used capsazepine,
a capsaicin antagonist, and TRPV1 … We provide evidence that stimulating TRPV1 mimics …

Suppression of adenosine A2a receptors alleviates bladder overactivity and hyperalgesia in cyclophosphamide-induced cystitis by inhibiting TRPV1

Y Yang, H Zhang, Q Lu, X Liu, Y Fan, J Zhu… - Biochemical …, 2021 - Elsevier
… There is evidence that adenosine A 2a receptors are involved in … The TRPV1 antagonist
capsazepine blocked bladder … We also found that inhibition of A 2a receptors reversed capsaicin-…

Differential engagement of inhibitory and excitatory cardiopulmonary reflexes by capsaicin and phenylbiguanide in C57BL/6 mice

RA Larson, MW Chapleau - American Journal of …, 2023 - journals.physiology.org
… (52) produced convincing evidence that … antagonist capsazepine and in TRPV1 globally
deficient mice. Off-target effects of systemically administered receptor/ion channel antagonists