… interest as therapeutic target in Alzheimer’s disease (AD), … derived products, as alternative
option for AD therapy. Indoline … as BuChE selective inhibitors while multitarget inhibitors …

As butyrylcholinesterase (BChE) plays a role in the progression of symptoms and pathophysiology
of Alzheimer’s disease (AD), selective inhibition of BChE over acetylcholinesterase (…

… by selectively inhibiting the catalytic activity of BuChE, while … of cholinesterases is regarded
as the major treatment option for … Common pathological processes in alzheimer disease and …

… Selective BChE inhibition has been regarded as a viable therapeutic approach in Alzheimer’s
disease… As of now, a limited number of selective BChE inhibitors are available. To identify …

… Alzheimer’s disease (AD) is characterized by severe basal … In line with this hypothesis, in
aged rats, selective inhibition of … of these inhibitors was studied by its removal or replacement …

… is the replacement of aromatic residues in the active site of AChE with aliphatic ones in BuChE,
which in turn leads to enzyme selectivity [… involved during Alzheimer disease progression …

… considering structural differences in their peripheral site, exploiting a moiety replacement
approach based on the potent and selective hAChE drug donepezil. Hence, two small series of …

… activity of 0.012, fit value of 10.02 could be further subjected to drug development and
forwarded as better alternatives to the current batch of medicines used for the treatment of AD. …

… the late stage of Alzheimer’s disease (AD), development of selective BChE inhibitors is of
vital … Moreover, AChE knockout mice models indicated that BChE can potentially substitute for …

… In addition, Butyrylcholinesterase (BuChE) has also been … A similar but much smaller
difference in selectivity was … with cholinesterase inhibition, they may be an attractive alternative to …