… and rats, neuronal lesions produced in the retrotrapezoid nucleus … substantially raised the
carbon dioxide apneic threshold, … that mice with selective genetic depletion of retrotrapezoid …

… whether reduction in PHOX2B expression in chemosensitive … the role of PHOX2B in RTN
neurons, we performed selective … a significant increase in the fraction of Nmb + /PHOX2B - was …

… exhibit not only a reduced number of retrotrapezoid nucleus (RTN) neurons but … mice,
chemogenetic stimulation of Phox2b-expressing NTS neurons produces a long-lasting increase …

… RTN lesions virtually eliminate the breathing stimulation … of Phox2b or Lbx1 prevent RTN
development in mice and … Phox2b is the only one that remains expressed in adulthood. RTN …

… adult rats revealed labeled phox2b-expressing neurons within … assess the selectivity of the
lesions, we analyzed Phox2b/TH-… as well as the increase in apneic threshold reported in vivo (…

… that chronic lesions of Phox2b-expressing NTS neurons had … of Phox2b-expressing NTS
neurons increases baseline MV … in Phox2b mutants targeting retrotrapezoid nucleus neurons. J …

… that the selective activation of Phox2b + /TH − neurons in the RTN elicits an increase in …
The Phox2b-expressing neurons of the RTN region may also influence the activity of the non…

… that mutant Phox2b expression in the visceral motor neuron … neurons, retrotrapezoid nucleus
RTN, and visceral motor … a severe apneic phenotype in mice expressing Phox2b Δ8 in the …

… 43% of Phox2b-expressing neurons from Phox2b-EGFP mice displayed a sustained or transient
increase in … to proportional lesions of CO 2 /H + -sensitive Phox2b-expressing neurons. …

… arousal and blood pressure increases when directly stimulated. … than Phox2b immunoreactivity,
which is also present in … RTN-Lesion rats; therefore, we assume that the loss of NK1R + …