… 1 A sketch of the haematopoietic stem cell bone marrow … effects on HSCs and haematopoietic
progenitor cells (HPCs). … progenitor cells but also promotes HSC survival and bone …

… HSCs are kept dormant in the bone marrow (BM) under normal … 11-fold increase in HSCs
with self-renewing and multi-lineage … can be expanded as non-adherent ‘mesenspheres’. The ‘…

… HSC niche function in cultured bone marrow-derived MSCs. … Mesensphere formation assays
were done by plating empty … (c) Self-renewing sphere-forming capacity was assessed by …

… Strategies for expanding hematopoietic stem cells (HSCs) … can promote ex vivo human
umbilical cord blood HSC expansion… that self-renewing murine mesenspheres are able to transfer …

… of hematopoietic stem cell (HSC) niche in bone marrow (BM) … in a model for 3-D mesenspheres
[31]. However, the dynamic … in the self-renewing expansion of hematopoietic progenitors (…

… mouse bone marrow mesenchymal stromal/stem cells (MSC) … to stimulate long-term
self-renewing hematopoietic stem cell (LT-… -contact dependent but rather stimulated by …

… ) inhibit, the self-renewal and expansion of HSCs from mouse bone marrow (BM) in vitro. The
opposite … More importantly, unlike human MSCs and BM mesenspheres, which promote the …

… hematopoietic stem cells (HSCs), to the highly proliferative … rather than a single multipotent
self-renewing stem cell. As a “… into spheres called mesenspheres and expand. These …

… presence of blood-forming stem cells in the bone marrow (BM… was actually key to induce
self-renewing divisions of HSC.73 … between human fetal BM CD34 + cells and mesenspheres …

… of the adult bone marrow haematopoietic stem cell (HSC) … to support expansion of
haematopoietic progenitor cells in vitro … -Fs) or mesenspheres (nonadherent mesenchymal …