[HTML][HTML] Sema4D/Plexin-B1 promotes the progression of osteosarcoma cells by activating Pyk2-PI3K-AKT pathway

C Li, L Wan, P Wang, X Guan, C Li… - … of Musculoskeletal & …, 2021 - ncbi.nlm.nih.gov
Semaphorins are related to immune response, cell migration, … Semaphorin 4D (Sema4D) is
an important member of the … been reported to induce vascular endothelial cell migration and …

Semaphorin 4D as a guidance molecule in the immune system

E Kuklina - International Reviews of Immunology, 2021 - Taylor & Francis
… to Plexin B1 in COS-7 cells enhances the Sema4D-induced activation of RhoA and …
endothelial cells, dependent both on Met [Citation6] and on the non-receptor tyrosine kinases Pyk2

A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib

T Sun, L Yang, H Kaur, J Pestel, M Looso… - Journal of Cell …, 2017 - rupress.org
… -B1 containing semaphorins and a plexin-semaphorin-integrin (PSI… the ecPlxnB1-induced
effects on cancer cell migration are … endothelial cells, which regulates the migration of DCs into

Emerging roles and mechanisms of semaphorins activity in cancer

C Bica, A Tirpe, A Nutu, C Ciocan, S Chira, ES Gurzau… - Life Sciences, 2023 - Elsevier
… – intracellular tyrosine kinases such as PYK2, FAK, Src family … -Fc successfully repressed
cell migration induced by VEGF, thus … angiogenesis through stimulation of endothelial cells (…

Semaphorin 4D Induces Vasculogenic Differentiation of Dental Pulp Stem Cells

N Al Turkestani, Z Zhang, JE Nör - Dentistry Journal, 2023 - mdpi.com
… unstimulated and SEMA4D-stimulated endothelial cells [54]. … activation by SEMA4D
induces angiogenesis, cytoskeletal reorganization, and the migration of endothelial cells through

The role of semaphorin 4D in bone remodeling and cancer metastasis

K Lontos, J Adamik, A Tsagianni, DL Galson… - Frontiers in …, 2018 - frontiersin.org
… stimulate PYK2 to induce cell invasiveness and migration. (… endothelial cells, Sema4D/Plexin-B1
signals stimulate PI3K-Akt to activate PYK2 and Src to control endothelial cell migration

Expression of MT1-MMP in Head and Neck Squamous Cell Carcinomas (HNSCCs) and Endothelial Cells is Regulated by Hypoxia and Semaphorin 4D (Sema4D)

A Bugshan - 2016 - archive.hshsl.umaryland.edu
… This activates Pyk2, which results in the phosphorylation of PI3K, Akt and Erk1/2, a … for
MT1-MMP activation. This enhances endothelial cell migration to induce angiogenesis. This study …

Neuroimmune semaphorin 4A in cancer angiogenesis and inflammation: a promoter or a suppressor?

AS Iyer, SP Chapoval - International Journal of Molecular Sciences, 2018 - mdpi.com
endothelial cells) migration in transwell chamber using VEGF alone or in combination with
several semaphorins… lipid chaperone which is induced in endothelial cells by VEGF exposure. …

Neuroimmune semaphorin 4A in cancer angiogenesis and inflammation

A Iyer, SP Chapoval - 2018 - preprints.org
… We did not detect Plexin B1 or Tim-2 expression on lung endothelial cells in mouse tissues
Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, …

Semaphorins 4A and 4D in chronic inflammatory diseases

SP Chapoval, Z Vadasz, AI Chapoval, E Toubi - Inflammation research, 2017 - Springer
… potential therapeutic target limiting Treg cell-mediated tumor-induced tolerance. … endothelial
cells promotes endothelial cell migration and tubulogenesis thus regulating tumor-induced