… Serotonin [5-hydroxytryptamine (5-HT)] is synthesized from tryptophan … pancreatic β cells,
5-HT plays pivotal roles in compensating for physiological insulin resistance during pregnancy…

… serotonin regulates β-cell proliferation through serotonin receptor 2B (HTR2B) in an
autocrine/paracrine manner during … are simultaneously increased during pregnancy. 5-HT …

… While β-cell mass increases during pregnancy and starts to return … β-cell mass during this
period is regulated remains unclear. To address this issue in mice, we quantified β-cell mass …

… functional change during pregnancy is the capacity of some beta cells to produce serotonin.
… and potential effects of pregnancy-related serotonin production in beta cells, considering …

… It is still unclear whether serotonin is relevant for … beta cells produce and secrete serotonin
when stimulated with increases in glucose concentration. Serotonin secretion from beta cells …

… Given the importance to understand beta cell serotonin during pregnancy, and the fact that
… of serotonin/Htr2b receptor-regulated beta cell proliferation during pregnancy using three …

… endocrine factor regulating maternal β-cell insulin secretion … in regulating pancreas endocrine
function during pregnancy. … to serotonin receptors on β-cells and regulates GSIS during …

… Serotonin synthesis within the pancreas contributes to the two- to threefold increase in β-cell
mass that occurs during pregnancy … GABA formation by pancreatic beta cells at the level of …

… GLP-1 regulate serotonin synthesis in beta cells, we … serotonin increase during pregnancy
[32]. So far, the effects of the down-regulation of serotonin synthesis by GCs on beta-cell mass …

… secretion during pregnancy48; thus, pregnant Htra3a knockout mice develop impaired
glucose tolerance despite normal β-cell mass. With this in mind, it might be speculated that β-cell–…