Sex influences in behavior and brain inflammatory and oxidative alterations in mice submitted to lipopolysaccharide-induced inflammatory model of depression
BSF Mello, AJM Chaves Filho, CS Custódio… - Journal of …, 2018 - Elsevier
Peripheral inflammation induced by lipopolysaccharide (LPS) causes a behavioral
syndrome with translational relevance for depression. This mental disorder is twice more
frequent among women. Despite this, the majority of experimental studies investigating the
neurobiological effects of inflammatory models of depression have been performed in
males. Here, we sought to determine sex influences in behavioral and oxidative changes in
brain regions implicated in the pathophysiology of mood disorders (hypothalamus …
syndrome with translational relevance for depression. This mental disorder is twice more
frequent among women. Despite this, the majority of experimental studies investigating the
neurobiological effects of inflammatory models of depression have been performed in
males. Here, we sought to determine sex influences in behavioral and oxidative changes in
brain regions implicated in the pathophysiology of mood disorders (hypothalamus …
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