… selectively deliver drugs to sites of vascular obstruction. We … We describe the development
of Shear Activated Nano-… activation, a shear activated nano-therapeutics has been developed …

… Recently, SANTs have been proposed as an interesting option to address targeted drug
delivery in clot-obstructed blood vessels. SANTs are micrometric clusters of polymeric …

… The human aorta is a high-risk area for vascular diseases, … a promising shear-activated
targeted nanoparticle drug delivery … drugs on the blood vessel wall is suggested to present in …

… Obstruction of blood vessels, commonly induced by … for shear-response drug release at
stenotic blood vessels.[28] An … preferentially release drugs in the constricted blood vessels with …

… widely in the realm of nanotherapeutics is shear stress. As … efficient, shear-activated DDS to
protect blood vessels against … of shear flow for drug release in obstructed blood vessels. The …

… obstruct blood flow across the circuit and harm blood vessels … bypass (TEB) with shear-activated
nanotherapeutic (SA-NT). … acid) (PLGA) shear-activated nanotherapeutics (SA-NTs) …

… to induce the formation of new blood vessels, which is also … of nano-sized drug delivery
systems and the subsequent … applied liposomes as drug carriers in drug delivery systems. The …

… have recently been researched as stimuli to trigger drug delivery. … of shear-activated DDSs
as well as provide future … constricted blood vessel site and release drugs. Modified from [73]. …

… the development of targeted nano-drug delivery systems are … solid matter in the heart and
blood vessels of mammals. This … , thereby improving drug delivery to the area of obstruction. …

… nanotherapeutics that can specifically target drugs to flow-obstructed blood vessels and …
to be utilized in the shear-activated drug targeting delivery. Hemodynamic shear stress is an …