Simultaneous administration of bromodomain and histone deacetylase I inhibitors alleviates cognition deficit in Alzheimer's model of rats
Abstract Background Histone deacetylases (HDACs) target various genes responsible for
cognitive functions. However, chromatin readers, particularly bromodomain-containing
protein 4 (BRD4), are capable to change the final products of genes. The objective of this
study was to evaluate the simultaneous effects of inhibition of HDACs and BRD4 on spatial
and aversive memories impaired by amyloid β (Aβ) in a rat model of Alzheimer's disease
(AD) considering CREB and TNF-α signaling. Methods Forty male Wistar rats aged 3 months …
cognitive functions. However, chromatin readers, particularly bromodomain-containing
protein 4 (BRD4), are capable to change the final products of genes. The objective of this
study was to evaluate the simultaneous effects of inhibition of HDACs and BRD4 on spatial
and aversive memories impaired by amyloid β (Aβ) in a rat model of Alzheimer's disease
(AD) considering CREB and TNF-α signaling. Methods Forty male Wistar rats aged 3 months …
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