… simvastatin inhibited the proliferation of colon cancer cells and suppressed the expression of
IGF-1R and IGF-1-induced ERK/Akt activation in HT-29 cells. … time that simvastatin induced …

… statins suppress proliferation and induce apoptosis of breast … time-related responses
upon exposure to simvastatin, … Thus, simvastatin appears to negatively regulate activation of …

… programmed cell death or apoptosis in cancerous cells.[ 14 … Fluorescence-activated cell
sorter was used to examine the … [ 31 ] Furthermore an inverse correlation between expression of …

… as a close correlation between bladder cancer and cell cycle. (c) … BCa cells simvastatin had
no significant effect on apoptosis … could be activated by simvastatin-induced dysregulation of …

… Lung cancer is the leading cause of cancer-related death … simvastatin and pyroptosis of the
human lung cancer cells A549 … In our study, pyroptosis induced by simvastatin by activating …

… Here we show that simvastatin-induced apoptosis was … Simvastatin (10 μM, 48 h) failed to
activate caspase-8 but did … with cancer was associated with reduced cancer-related mortality …

… -9, a protein related to tumor cell metastasis; 3) Inhibition of … ) Activation of caspase-9 and
caspase-3, which provokes cell … simvastatin inhibits cancer cell growth by inducing apoptosis …

… Cell proliferation and expression of apoptosis-related and EGFR … in EGFR-TKI-induced
apoptosis. In EGFR-sensitive lung … cancer by activation of the nuclear factor-κB and inhibition of …

… illustrated that simvastatin diminished the activation of RhoA … survival of cancer cells by
inducing growth arrest and apoptosis [19,… Simvastatin could reduce metastasis-related activity by …

… To further investigate whether cell cycle-related molecule expression levels … Simvastatin
inhibits cell growth and induces apoptosis and G0/G1 cell cycle arrest in hepatic cancer cells. Int …