Foxp3-independent mechanism by which TGF-β controls peripheral T cell tolerance
SA Oh, M Liu, BG Nixon, D Kang… - Proceedings of the …, 2017 - National Acad Sciences
… OT-II T cells that coexpress floxed Tgfbr2 and the estrogen-… -infiltrating T cells was not
significantly reduced in Csf2rb −/− … for Foxp3-independent TGF-β regulation of peripheral T cell …
significantly reduced in Csf2rb −/− … for Foxp3-independent TGF-β regulation of peripheral T cell …
Intricacies of TGF-β signaling in Treg and Th17 cell biology
… Regulatory T (Treg) and Th17 cells are critical Th cell types … responses, TGF-β1 mainly
targets T cells because T-cell-specific … region to reduce inhibitory histone markers of H3K27me3 […
targets T cells because T-cell-specific … region to reduce inhibitory histone markers of H3K27me3 […
CD4+ CD25+ regulatory T cells in tumor immunity
X Chen, Y Du, XQ Lin, Y Qian, T Zhou… - International …, 2016 - Elsevier
… (Foxp3) is a critical regulator of CD4 + CD25 + regulatory T … granule release, and coexpression
of coinhibitory receptors PD-… of TGF-β1 and IL-10 and a low CD8(+)/Foxp3(+) CD25(+) T-…
of coinhibitory receptors PD-… of TGF-β1 and IL-10 and a low CD8(+)/Foxp3(+) CD25(+) T-…
TGF-β Affects the Differentiation of Human GM-CSF+ CD4+ T Cells in an Activation- and Sodium-Dependent Manner
S Éliás, A Schmidt, V Kannan, J Andersson… - Frontiers in …, 2016 - frontiersin.org
… CD4 + T cells, TGF-β1 or TGF-β3 was found to decrease GM-… -γ, FOXP3, IL-17, CD25) that
we studied in human cells before. … co-expressing other T cell subset markers on the single-cell …
we studied in human cells before. … co-expressing other T cell subset markers on the single-cell …
TβRIII is induced by TCR signaling and downregulated in FoxP3+ regulatory T cells
S Ortega-Francisco, M de la Fuente-Granada… - Biochemical and …, 2017 - Elsevier
… /6 background) co-expressing FoxP3 and enhanced GFP were … and FoxP3 EGFP knock in
mice and single cell suspensions … (1 μg/ml), with or without TGFβ1 at 10 ng/ml, in complete …
mice and single cell suspensions … (1 μg/ml), with or without TGFβ1 at 10 ng/ml, in complete …
[HTML][HTML] Single-cell transcriptional profiling reveals signatures of helper, effector, and regulatory MAIT cells during homeostasis and activation
… , and IFI44L and decreased expression of CD69 and CD25. C4 was distinguished … FOXP3
is a transcriptional regulator of conventional CD4 + Tregs and is often coexpressed with CD25 …
is a transcriptional regulator of conventional CD4 + Tregs and is often coexpressed with CD25 …
Multilayer regulation of CD4 T cell subset differentiation in the era of single cell genomics
… These Foxp3 + T cells suppress effector T cell and B cell … Interestingly, the analysis of
networks of coexpressed genes … “nonpathogenic” Th17 cells (induced by IL-6 and TGF-β1) but to …
networks of coexpressed genes … “nonpathogenic” Th17 cells (induced by IL-6 and TGF-β1) but to …
Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells
C Ferreira, L Barros, M Baptista, B Blankenhaus… - Nature …, 2020 - nature.com
… CD69 with about half co-expressing CD103 (Supplementary … We hypothesized that reduced
T RM cell numbers in Foxp3 … reg cells, which do not show differential expression for TGF-β1 …
T RM cell numbers in Foxp3 … reg cells, which do not show differential expression for TGF-β1 …
Regulatory T-cell depletion alters the tumor microenvironment and accelerates pancreatic carcinogenesis
Y Zhang, J Lazarus, NG Steele, W Yan, HJ Lee… - Cancer discovery, 2020 - AACR
… not shown), FOXP3 was coexpressed with CTLA4 and IL2RA… , including Tregs, are the
sources of TGFβ1 within the tissue. … a 40-μmol/L mesh to obtain single cells. Up to 1 × 10 7 …
sources of TGFβ1 within the tissue. … a 40-μmol/L mesh to obtain single cells. Up to 1 × 10 7 …
Characterization of CD4+ and CD8+ T cells responses in the mixed lymphocyte reaction by flow cytometry and single cell RNA sequencing
A Mangelinck, A Dubuisson, E Becht… - Frontiers in …, 2024 - frontiersin.org
… cells (Thelper) and regulatory T cells (Treg) for CD4 + T cells … Strikingly, this CD4 + FoxP3
+ CD25 hi Treg cluster … expressing Ki-67 + CD25 + and co-expressing ICPs correlated with …
+ CD25 hi Treg cluster … expressing Ki-67 + CD25 + and co-expressing ICPs correlated with …