[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene
S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
… Carriers of small isoforms with up to 22 kringle IV domains … kringle consisting of two short
exons, spaced by a mostly ≈4 … by several functional single nucleotide polymorphisms (SNPs) (…
exons, spaced by a mostly ≈4 … by several functional single nucleotide polymorphisms (SNPs) (…
Assessing the Structure-function Relationships of the Apolipoprotein (a) Kringle IV Sub-Type 10 Domain
J Matthew - 2019 - search.proquest.com
… single nucleotide polymorphisms (… -kringle IV (14K), 6kringle IV (6K), and a construct
containing KIV10, KV, and the protease-like domain (10-P) in the pRK5 plasmid, and a wildtype apo(…
containing KIV10, KV, and the protease-like domain (10-P) in the pRK5 plasmid, and a wildtype apo(…
The kringle IV type 2 domain variant 4925G> A causes the elusive association signal of the LPA pentanucleotide repeat
R Grüneis, H Weissensteiner, C Lamina… - Journal of Lipid …, 2022 - ASBMB
… for apolipoprotein(a) [apo(a)], which consists of 10 different kringle IV domains (KIV-1 to
KIV-10)… repeat (STR) located 1.3 kb upstream from the first exon of LPA (hg19 chr6:161,086,617–…
KIV-10)… repeat (STR) located 1.3 kb upstream from the first exon of LPA (hg19 chr6:161,086,617–…
Assessing the structure-function relationships of the apolipoprotein (a) kringle IV sub-type 10 domain
MJ Borrelli - 2019 - ir.lib.uwo.ca
… single nucleotide polymorphisms (… -kringle IV (14K), 6kringle IV (6K), and a construct
containing KIV10, KV, and the protease-like domain (10-P) in the pRK5 plasmid, and a wildtype apo(…
containing KIV10, KV, and the protease-like domain (10-P) in the pRK5 plasmid, and a wildtype apo(…
Apolipoprotein (a) kringle-IV type 2 copy number variation is associated with venous thromboembolism
E Sticchi, A Magi, PR Kamstrup, R Marcucci, D Prisco… - … One, 2016 - journals.plos.org
… -2 size polymorphism and single nucleotide polymorphisms (… 7 repeats of the KIV-2 domain;
however, KIV-2 repeats … to have 10 (C10), 12 (C12), and 73 (C73) copies of the exon 4 of the …
however, KIV-2 repeats … to have 10 (C10), 12 (C12), and 73 (C73) copies of the exon 4 of the …
The Effect of Single Nucleotide Polymorphisms in Apolipoprotein (a) KIV Types 6-9 on Lipoprotein (a) Particle Assembly and Apolipoprotein (a) Secretion In Vitro
S Sayegh - 2018 - search.proquest.com
… Apo(a) possesses 10 distinguishable plasminogen like kringle IV (KIVn; n=110) domains,
each present in a single … that the human apo(a) gene further evolved as a combination of exon …
each present in a single … that the human apo(a) gene further evolved as a combination of exon …
A comprehensive map of single-base polymorphisms in the hypervariable LPA kringle IV type 2 copy number variation region [S]
… Approximately 90#x0025; of Lp(a) variance is controlled by the LPA gene, which contains
a 5.6-kb-large copy number variation [kringle IV type 2 (KIV-2) repeat] that generates >40 …
a 5.6-kb-large copy number variation [kringle IV type 2 (KIV-2) repeat] that generates >40 …
Lipoprotein (a) concentration, genetic variants, apo (a) isoform size, and cellular cholesterol efflux in patients with elevated Lp (a) and coronary heart disease …
C Stefanutti, L Pisciotta, E Favari, S Di Giacomo… - Journal of Clinical …, 2020 - Elsevier
… The kringle IV type 2 (KIV-2) domain is further expanded resulting … single-nucleotide
polymorphisms [SNPs] in the protease … on exon 26; in our study, we identified this variant in 4 …
polymorphisms [SNPs] in the protease … on exon 26; in our study, we identified this variant in 4 …
Nonsynonymous SNPs in LPA homologous to plasminogen deficiency mutants represent novel null apo (a) alleles [S]
BM Morgan, AN Brown, N Deo, TWR Harrop… - Journal of Lipid …, 2020 - ASBMB
… Imaging of the recombinant apo(a) proteins in conjunction with … correct folding of the apo(a)
kringle structure and mutations at … (a) kringles IV types 6 to 10 domain affect Lp(a) plasma …
kringle structure and mutations at … (a) kringles IV types 6 to 10 domain affect Lp(a) plasma …
Human genetics and the causal role of lipoprotein (a) for various diseases
F Kronenberg - Cardiovascular drugs and therapy, 2016 - Springer
… number of kringle IV (KIV) repeats in the LPA gene [1, 6]. … PLG contains five types of kringle
domains called KI to KV … Another SNP in the first exon of KIV type-2 introduces a stop codon …
domains called KI to KV … Another SNP in the first exon of KIV type-2 introduces a stop codon …