Novel, non-nitrocatechol catechol-O-methyltransferase inhibitors modulate dopamine neurotransmission in the frontal cortex and improve cognitive flexibility
S Byers, IP Buchler, M DePasquale, HL Rowley… - …, 2020 - Springer
… Catechol-O-methyltransferase (COMT) inhibitors modulate cortical dopaminergic function
and have been proposed as potential cognitive enhancers. Unfortunately, currently available …
and have been proposed as potential cognitive enhancers. Unfortunately, currently available …
Catechol-O-methyltransferase gene Val158Met polymorphism and obsessive compulsive disorder susceptibility: a meta-analysis
P Kumar, V Rai - Metabolic brain disease, 2020 - Springer
… Catechol-O-methyltransferase (COMT) is an important enzyme involved in the metabolic
inactivation of the dopamine … COMT inactivates dopamine in prefrontal cortex region of brain …
inactivation of the dopamine … COMT inactivates dopamine in prefrontal cortex region of brain …
The role of catechol-O-methyltransferase in processing affective stimuli
N Dalton - 2016 - ora.ox.ac.uk
… of dopamine and is one of the key regulators of dopamine levels in the prefrontal cortex. COMT
is … First identified by Axelrod in 1958, catechol-O-methyltransferase (COMT) is an enzyme …
is … First identified by Axelrod in 1958, catechol-O-methyltransferase (COMT) is an enzyme …
Balance between transmitter availability and dopamine D2 receptors in prefrontal cortex influences memory functioning
G Papenberg, N Karalija, A Salami… - Cerebral …, 2020 - academic.oup.com
… Catechol-O-Methyltransferase polymorphism served as genetic proxy for endogenous prefrontal
… For instance, the catechol-O-methyltransferase (COMT) Val158Met polymorphism gives …
… For instance, the catechol-O-methyltransferase (COMT) Val158Met polymorphism gives …
[PDF][PDF] Generation of membrane-bound catechol-O-methyl transferase deficient mice with disctinct sex dependent behavioral phenotype
A Tammimaki, A Aonurm-Helm… - J Physiol …, 2016 - researchportal.helsinki.fi
… prefrontal cortical extracellular fluid dopamine levels pointing to the site-specific alterations
in dopamine … Genetic dissection of the role of catechol-O-methyltransferase in cognition and …
in dopamine … Genetic dissection of the role of catechol-O-methyltransferase in cognition and …
[HTML][HTML] Brain network connectivity and association with catechol-o-methyltransferase gene polymorphism in Korean attention-deficit hyperactivity disorder children
JH Park, YD Son, Y Kim, DH Han - Psychiatry Investigation, 2020 - ncbi.nlm.nih.gov
… The availability of DA and NE in the prefrontal cortex is mainly affected by COMT enzymes
[ 56 ]. Recent research showed that altered dopaminergic and noradrenergic tone, affected by …
[ 56 ]. Recent research showed that altered dopaminergic and noradrenergic tone, affected by …
[PDF][PDF] Elimination of extracellular dopamine in the medial prefrontal cortex of conscious mice analysed using selective enzyme and uptake inhibitors
A Tammimaki, A Aonurm-Helm, M Kaenmaki… - J Physiol …, 2016 - jpp.krakow.pl
… Estimates of the proportional role of COMT in the rodent prefrontal cortical dopamine clearance
… Site specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal …
… Site specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal …
Estradiol and the catechol-o-methyltransferase gene interact to predict working memory performance: a replication and extension
… Decades of evidence across taxa have established the importance of dopamine (DA) … using
the catechol-o-methyltransferase (COMT) gene as a proxy for basal prefrontal DA tone. The …
the catechol-o-methyltransferase (COMT) gene as a proxy for basal prefrontal DA tone. The …
Distinct roles for dopamine clearance mechanisms in regulating behavioral flexibility
C Korn, T Akam, KHR Jensen, C Vagnoni… - Molecular …, 2021 - nature.com
… particularly by catechol-O-methyltransferase (COMT), is more prominent in prefrontal cortex
(… These results, however, contrast with a report of differences in dopamine overflow in COMT …
(… These results, however, contrast with a report of differences in dopamine overflow in COMT …
The impact of Val108/158Met polymorphism of catechol-O-methyltransferase on brain oscillations during working memory
M Altamura, B Elvevåg, TE Goldberg, FW Carver… - Neuroscience …, 2016 - Elsevier
… Therefore, modification of gamma oscillations by COMT polymorphism points toward
abnormal dopamine–glutamate interactions within prefrontal networks. The differences between …
abnormal dopamine–glutamate interactions within prefrontal networks. The differences between …