… Catechol-O-methyltransferase (COMT) inhibitors modulate cortical dopaminergic function
and have been proposed as potential cognitive enhancers. Unfortunately, currently available …

… Catechol-O-methyltransferase (COMT) is an important enzyme involved in the metabolic
inactivation of the dopamine … COMT inactivates dopamine in prefrontal cortex region of brain …

… of dopamine and is one of the key regulators of dopamine levels in the prefrontal cortex. COMT
is … First identified by Axelrod in 1958, catechol-O-methyltransferase (COMT) is an enzyme …

… Catechol-O-Methyltransferase polymorphism served as genetic proxy for endogenous prefrontal
… For instance, the catechol-O-methyltransferase (COMT) Val158Met polymorphism gives …

… prefrontal cortical extracellular fluid dopamine levels pointing to the site-specific alterations
in dopamine … Genetic dissection of the role of catechol-O-methyltransferase in cognition and …

… The availability of DA and NE in the prefrontal cortex is mainly affected by COMT enzymes
[ 56 ]. Recent research showed that altered dopaminergic and noradrenergic tone, affected by …

… Estimates of the proportional role of COMT in the rodent prefrontal cortical dopamine clearance
… Site specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal …

… Decades of evidence across taxa have established the importance of dopamine (DA) … using
the catechol-o-methyltransferase (COMT) gene as a proxy for basal prefrontal DA tone. The …

… particularly by catechol-O-methyltransferase (COMT), is more prominent in prefrontal cortex
(… These results, however, contrast with a report of differences in dopamine overflow in COMT …

… Therefore, modification of gamma oscillations by COMT polymorphism points toward
abnormal dopamine–glutamate interactions within prefrontal networks. The differences between …