… NK cells and stimulates the generation of regulatory T cells … β (tumor suppression) and the
late gene response (tumor promotion) … as in pancreatic and colon cancers, Smad4 and Smad2 …

… functions independently of TGF-β signaling in T cells (17, 18)… to the development of
gastrointestinal cancer lesions in mice … In CD4 + T cells, SMAD4 mediates the repression of the …

… of SMAD4 from colorectal cancer cell lines also result in … IL-21, SMAD4 could suppress the
differentiation of Th17 cells, by … b/SMAD4 signaling was important for T cell function, SMAD4 …

… Here we report that in the absence of TGF-β signaling in T cells, the production of proinflammatory
cytokines is significantly increased and IFN-γ expression is down-regulated through a …

… Intestinal cancer Single nucleotide deletion of SMAD4 exon … The T cell–specific SMAD4
knockout models phenocopy … , suppression of TGF-β signaling either in the intestinal cells or the …

… /SMAD4 signaling pathway plays a tumor suppressive role at early stages, mainly by inducing
cell … SMAD4-deficient colorectal tumor cells secreted more CCL9 and CCL15, chemokines …

… by specific deletion of SMAD4 within T cells can promote … and SMAD4 as independent tumor
suppressors in gastric cancer. … TGFβ signaling pathway undoubtedly has tumor suppressive …

… cells, contributing to greater susceptibility to colon cancer. … that SMAD4− UCACs exhibited
an increase in overall T cell … function of SMAD4 to regulation of CCL20/CCR6 signaling, …

… genetic depletion of SMAD4 in colon cancer cells allows TGF-β-… to induce BMP signaling to
switch from tumor suppression to … Infiltrating T cells are activated through signals to the T-cell …

… of Smad4 in T cells with intact epithelial expression of Smad4 in … role for TGFβ signaling in
suppressing colonic epithelial cell … UC-associated colon cancers were negative for SMAD4 …