… Our data suggested that HIF-1α might be an upregulator of the SNAIL gene and HIF-1α-SNAIL-E-cad …
Such results confirmed that the SNAIL gene might be a target gene of HIF-1α. …

… The former is the most important factor induced by hypoxia because HIF-1α controls the
expression of target genes containing hypoxic response elements (HREs) in their promoters. …

… study showed that HIF-1α might modulate EMT via the Snail and β-catenin pathways in PQ
poisoning-induced early pulmonary fibrosis. Therefore, HIF-1α may be a therapeutic target for …

… , phosphorylated TOPK, HIF-1α and Snail was significantly … mRNA and protein levels
of HIF-1α and Snail. Interestingly, TOPK … The ON-TARGET plus nontargeting pool and ON-TARGET …

… of Snail can influence the level of downstream genes, we screened and identified the
downstream target genes by … The downstream target genes regulated by Snail and the related …

… relative expression of the target gene was calculated by 2… HIF-1α, Snail and E-cadherin,
Spearman method was adopted to verify it, and we found that the expression of HIF-1α and Snail …

… (Snail) and five (Slug) zinc fingers and is involved in the binding of the proteins to the target
gene … demonstrate that HIF-1α regulates the activation of EMT, increasing the Snail level in …

… significantly prevent or delay this process via inhibiting HIF-1α and snail. Therefore, ING4
may be a therapeutic target for preventing the occurrence and progression of renal fibrosis. …

… We emphasize once again that in our study, the HIF-1α and Snail expression coefficients
were significantly higher in the Luminal A subtype of BC resistant to chemotherapy. Thus, our …

… In this study, we designed two shRNA sequences targeting IDH1, and the individual … among
IDH1, HIF-1a, twist, and snail. As shown in Table 3, the expression levels of HIF-1a and twist …