… depolarisation and altered pH regulation. Together, recent findings relating to elevated …
Na + in the tumour microenvironment and how this may be regulated by several classes of Na + …

… In conclusion, a microenvironment with high concentrations of Na + can have direct effects
on various types of immune cells — for example, boosting T H 17 cell differentiation and …

… play a critical role in cancer development and progression. High salt is known to mediate
several … In this review, we discuss the current understanding of the salt mediated metabolic and …

… While the role of osmolarity in regulation of NHE1 in tumors has, to our knowledge, not been
studied, … The roles of Na + /HCO 3 − cotransporters in the stromal cells in a tumor setting are …

… The H + -dependent Pi transporter could confer on tumors a biological advantage by …
sodium-dependent Pi transport is saturated by high extracellular Pi in the tumor microenvironment (…

… to the upregulated expression of MCT and Na + /H + exchanger. … to the acid tumor
microenvironment, which gives the tumor a … This suggests that the acidic tumor microenvironment …

… Moreover, this isoform is involved in the pH regulation and cellular connection in association
with ion exchanger and Na + -HCO3- co-transporters. Studies have shown that CAIX …

… tumor microenvironment in response to oral NaHCO 3 therapy shows no overall net effect on
breast tumor-free survival or primary tumor … breast cancer cells by genetic disruption of Na + …

… regulation in the tumor microenvironment, advantages to interfering with the function of pH
regulatory machinery, the impact of pH homeostasis … their dependence on sodium: the sodium-…

… of tumour microenvironment. Novel therapeutic approaches that can target various tumour
microenvironment … and a tumor penetrating peptide iNGR-sodium stearoyl lactylate (SSL), …