… The T H 1/IFN-γ down-regulation that we demonstrate is in agreement not only with the
concomitant reciprocal up-regulation of T H 2 cell responses but also with the previous …

… combat the most aggressive tumors. To date… tumor metastases depend on particular metabolic
pathways that facilitate reciprocal interactions between cancer cells and host homeostatic …

… react to a low pH to maintain tissue homeostasis. In the BM … As a part of the tumor
microenvironment (TME), mineralized … extruders have been associated with cancer [2], like Na + /H …

… Rapid exposure to ATP trigger opening of a cation-selective channel allowing Na + and Ca
2+ … Opening of the P2X 7 pore disrupts intracellular homeostasis, leading to cell death [5,6,7]. …

… The pH in tumour cells and the tumour microenvironment … The homeostasis of pH e and pH
i is very important for all kinds … The alkaline agents include sodium bicarbonate and trisodium …

… contribute to tumor immune … tumor-derived lactate and tumor acidity restrict immunity. To
our knowledge, this review outlines the most recent insights on how tumor microenvironment …

… (NK) cells, and dendritic cells, contributing to tumor cell immune escape. It is also … tumor
growth and invasion. In this review, we have discussed the lactate-based pH regulation in tumor …

… been developed for various cancers, including chemotherapy, … alterations in tumor cells,
the tumor microenvironment (TME) … Here, we propose that the adaptive mechanisms of tumor …

… The acidic tumor microenvironment favors its plasma … STIM1, and a voltage-activated sodium
channel (Nav1.6), and an … acidic tumor microenvironment affects epigenetic regulation of …

… as a metabolic fuel for tumor cells, as well as its participation in drug resistance (Figure 1).
The importance of the suppressive acidic tumor microenvironment induced by lactate is also …