Spanethosomes as a novel topical carrier for silymarin in contrast to conventional spanlastics: Formulation development, in vitro and ex vivo evaluation for potential …
Spanlastics which are nanovesicles composed of nonionic surfactant and edge activator
have recently emerged as a promising topical/transdermal drug delivery carrier, to overcome
the challenging properties of the stratum corneum. In the current work, a novel vesicular
system; spanethosomes, was developed by introducing ethanol within spanlastics, to
combine both the skin penetration enhancing ability of spanlastics and the fluidizing effect of
ethanol. For comparative purposes, spanethosomes and spanlastics loading silymarin were …
have recently emerged as a promising topical/transdermal drug delivery carrier, to overcome
the challenging properties of the stratum corneum. In the current work, a novel vesicular
system; spanethosomes, was developed by introducing ethanol within spanlastics, to
combine both the skin penetration enhancing ability of spanlastics and the fluidizing effect of
ethanol. For comparative purposes, spanethosomes and spanlastics loading silymarin were …
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