Effects of the dietary carbohydrate–fat ratio on plasma phosphatidylcholine profiles in human and mouse

M Inoue, N Senoo, T Sato, Y Nishimura… - The Journal of nutritional …, 2017 - Elsevier
… species of fatty acids synthesized in the liver are affected by … aliquots of mouse plasma
or human serum were analyzed by … decreases hepatic PC (16:0/16:1) levels, a 16:1-CoA-specific

[HTML][HTML] … spectrometry-based profiling of phosphatidylcholine and phosphatidylethanolamine in the plasma and liver of acetaminophen-induced liver injured mice

YN Ming, JY Zhang, XL Wang, CM Li, SC Ma… - Lipids in health and …, 2017 - Springer
… The profiles of PC and PE in mice livers analyzed by LC-MS … b qRT-PCR analysis of the
mRNA levels of PC/PE synthesis … ), specific fragment (PC and LPC have the specific product of …

[HTML][HTML] Abnormal liver phosphatidylcholine synthesis revealed in patients with acute respiratory distress syndrome

A Dushianthan, R Cusack, MPW Grocott… - Journal of Lipid …, 2018 - ASBMB
Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis
analyzed in vivo. … Specificity and rate of human and mouse liver and plasma

[HTML][HTML] The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease

JN van der Veen, JP Kennelly, S Wan, JE Vance… - … et Biophysica Acta (BBA …, 2017 - Elsevier
… For example, inhibition of hepatic PC synthesis impairs very low density lipoprotein … in
plasma of liver-specific Pcyt1α −/− (LPcyt1α −/− ) were 50% lower than in control mice because of …

[HTML][HTML] Plasma phospholipids and fatty acid composition differ between liver biopsy-proven nonalcoholic fatty liver disease and healthy subjects

DWL Ma, BM Arendt, LM Hillyer, SK Fung… - Nutrition & …, 2016 - nature.com
… previously shown that the hepatic phosphatidylcholine (PC) … were examined for the present
study. Briefly, total RNA from … We have shown that specific plasma phospholipids differ …

[HTML][HTML] mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion

WJ Quinn, M Wan, SV Shewale… - The Journal of …, 2017 - Am Soc Clin Investig
… inhibition of hepatic mTORC1, we performed liver-specific ablation … in liver TAG in L-Raptor–KO
mice cannot be explained by … In summary, we have elucidated the signaling mechanisms …

A role for phosphatidylcholine and phosphatidylethanolamine in hepatic insulin signaling

JN Van Der Veen, S Lingrell, N McCloskey… - The FASEB …, 2019 - Wiley Online Library
… the role of hepatic phospholipid synthesis and metabolism in … , we analyzed DAG levels in
microsomal fractions of the liver. … A specific biochemical and cytological marker for a unique …

[HTML][HTML] Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease

EM Haberl, R Pohl, L Rein-Fischboeck… - Lipids in Health and …, 2020 - Springer
Phosphatidylcholine and lysophosphatidylcholine … The tumor specific lipid profile,
however, did not resemble the … at a comprehensive analysis of the liver lipidome of mice fed a …

Phosphatidylcholine transfer protein/StarD2 promotes microvesicular steatosis and liver injury in murine experimental steatohepatitis

HT Nicholls, JL Hornick… - … Gastrointestinal and Liver …, 2017 - journals.physiology.org
… -transfer protein (PC-TP) is a highly specific phosphatidylcholine-… route for phosphatidylcholine
synthesis within cells is … can promote hepatic insulin resistance (32), we tested whether …

From yeast to humans–roles of the Kennedy pathway for phosphatidylcholine synthesis

CR McMaster - FEBS letters, 2018 - Wiley Online Library
specific functions in cells such as in the synthesis of surfactant by the lung, the assembly of
VLDL by the liver, … , CTP:phosphocholine cytidylyltransferase is by far the most well studied of …