Specifics of fetuin‐A levels in distinct types of chronic heart failure
M Lichtenauer, B Wernly, V Paar, I Rohm… - Journal of clinical …, 2018 - Wiley Online Library
M Lichtenauer, B Wernly, V Paar, I Rohm, C Jung, A Yilmaz, UC Hoppe, PC Schulze…
Journal of clinical laboratory analysis, 2018•Wiley Online LibraryIntroduction Fetuin‐A has been described to correlate inversely with vascular calcification
both in animal models but also in patients with heart and renal disease. In this current study,
we sought to investigate whether fetuin‐A might be a useful marker for the discrimination of
ischemic (ICM) from dilated cardiomyopathy (DCM). Methods A total of 124 non‐consecutive
patients were included in this study, 59 patients suffered from ICM and 65 patients from
DCM. Serum samples were obtained during out‐patient visits and analyzed for fetuin‐A by …
both in animal models but also in patients with heart and renal disease. In this current study,
we sought to investigate whether fetuin‐A might be a useful marker for the discrimination of
ischemic (ICM) from dilated cardiomyopathy (DCM). Methods A total of 124 non‐consecutive
patients were included in this study, 59 patients suffered from ICM and 65 patients from
DCM. Serum samples were obtained during out‐patient visits and analyzed for fetuin‐A by …
Introduction
Fetuin‐A has been described to correlate inversely with vascular calcification both in animal models but also in patients with heart and renal disease. In this current study, we sought to investigate whether fetuin‐A might be a useful marker for the discrimination of ischemic (ICM) from dilated cardiomyopathy (DCM).
Methods
A total of 124 non‐consecutive patients were included in this study, 59 patients suffered from ICM and 65 patients from DCM. Serum samples were obtained during out‐patient visits and analyzed for fetuin‐A by ELISA.
Results
Median fetuin‐A concentration in the overall cohort was significantly lower in ICM patients compared to DCM patients (62.2±16.4 μg/mL vs. 129.6±56.6 μg/mL; P<.001). A positive correlation of fetuin‐A levels was found with BMI, cholesterol, LDL/HDL ratio and triglycerides and an inverse correlation with age (r=−.36; P<.001). Moreover, patients suffering from (stable) angina pectoris evidenced lower fetuin‐A levels compared to non‐symptomatic patients (73.1±22.7 μg/mL vs. 83.7±26.2 μg/mL; P=.047)
Conclusions
Fetuin‐A was shown to be a potential discriminator and biomarker for the differential diagnosis between ICM and DCM. Fetuin‐A levels might also be helpful in the process of diagnostic decision‐making in regards to invasive management or medical therapy.
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