… in testis development and spermatogenesis between WT and ASB17 −/− mice. Notably,
no … Even though the mice that lacked BCLW were normal, male BCLW-deficient mice were …

… W in primary mouse hematopoietic cells and to observations that Bcl-w–deficient mice have
no overt … While BCL-W is recognized for its critical function in spermatogenesis (8, 9), there is …

… This is supported by studies showing that loss of BCL-w was associated with defects in
spermatogenesis and small intestine cells in mice but had no deleterious effects in the majority of …

… We recently discovered BCLW, an antiapoptotic BCL2 family member thought only to
contribute to spermatogenesis, was overexpressed in diffuse large B-cell lymphoma (DLBCL) and …

… , and the lack of other defects in Bcl-w −/− mice [18,19,20], it … mice with other mutant mice
with spermatogenesis defects but no other abnormalities, such as spermatid maturation 1 mice …

… sterility of male mice. Despite this profound effect on spermatogenesis, the BCL-W-deficient
mice are otherwise … Thus, BCL-W has a very selective role in promoting spermatogenesis. …

… , except a modest rise in platelets (Mason et al., 2007), and bax-/- mice exhibit only mild
lymphoid hyperplasia and male sterility, the latter because proper spermatogenesis requires the …

Dysregulated expression of BCL-2 family proteins allows cancer cells to escape apoptosis.
To counter this, BH3-mimetic drugs that target and inhibit select BCL-2 prosurvival proteins to …

… We summarise the findings from gene-targeting studies in mice to discuss the specific roles
of … males are infertile, demonstrating a critical role for BCL-W in spermatogenesis [78, 79]. …

… Mice overexpressing the apoptosis-inhibitory Bcl-xL or Bcl-2 proteins in the male germinal …
spermatogenesis accompanied by sterility. Massive spermatogonia and a few spermatocytes …