… Endomorphin-1 (EM1) and endomorphin-2 (EM2) are two … underlying the analgesic effects
of the EMs in the spinal level can be … agonists endomorphins 1 and 2 have novel hypotensive …

… In addition, the antiallodynic activities of peripheral … and antibodies against endogenous
opioid peptides were … μ 2 -opioid receptor subtypes are localized in the spinal cord …

… their agonist activities and opioid receptor specificities [51]. … quinolyl, cyclohexyl, and 2adamantyl
exhibited MOP receptor … were capable of intensifying opioid-mediated analgesia [90]. …

… of endogenous mechanism that suppress and facilitate spinal … analgesic effects of some
endogenous opioid peptides and the … to MOR, spinal dynorphin and KOR activities are also …

… advantages and drawbacks of using endomorphin-1 (23) or … Endomorphin-1 (EM-1) and
-2 (EM-2) are endogenous, MOR… and at spinal levels [65], and displays an analgesic potency …

… release of endogenous opioid peptides. … analgesia compared to the parent peptide
endomorphin-1. Multiple antagonists and antibodies were used to explore the mechanisms of action …

… potency and longer duration of action relative to morphine. … that are based on the structures
of endogenous EM-1 and EM-… of pain state and test method, and 2) that morphine, but not …

… In 1997, two neuropeptide ligands named endomorphin-1 (EM… potent antinociceptive activities
in acute pain at the spinal and … the involvement of release of endogenous opioid peptides. …

… In the present study, we further examined their spinal analgesia … antibodies against
endogenous opioid peptides were used to … Analogs 3 and 4 were less potent than analogs 1 and 2 …

… that intrathecal (it) administration of endomorphin-1 (EM-1), … and restored the antinociception
at 1.5 and 2 h. Nevertheless, EM… Opioid peptides are expected as effective analgesics in the …