… Expert opinion: A better understanding of the incidence and clinical significance of statin
DDIs … providing their patients with an evidence-based, safe and cost-effective clinical support. …

… The overall clinical impact of a DDI can range from mild to life-threatening. … the clinical
significance of a DDI depends on both medication-specific and patient-specific factors. Medication-…

… The most common drugs associated with statin drug interactions are glucocorticoids,
antipsychotics, HIV protease inhibitors, azole antifungal agents, immunosuppressive …

… clearance is essential information to determine the significance of drug-drug interactions.
The inhibitory effect of different macrolides on OATP1B1/1B3 transporters was evaluated in an …

… ; however, the clinical significance of this is unknown. Some statin drugs are potentially
diabetogenic … • Pravastatin has the least drug interactions amongst the statin drugs and should be …

… Thus, the safety and adverse effects of statins are of special concern especially in patients
affected by multiple chronic conditions requiring concomitant therapies at risk of DDIs such as …

… effects of statins, adverse events associated with but not necessarily caused by statins, and
drug interactions. In … with worsening renal function, and of unclear clinical significance. Other …

… of statin DDIs, the clinical significance of ARTs effects on these pathways is the fact that these
are also shared by statins. … and statins, reviewing mechanisms and clinical considerations. …

… Additionally, there is a greater potential clinical impact from drug-drug interactions in
older people because of age-related physiological changes in the pharmacokinetic and …

… Since our review in 2015 [Citation10], few studies have evaluated the pharmacokinetic impact
of drug–drug interactions in human clinical trials for fluvastatin, lovastatin, and pitavastatin. …