… Whilst the results of disease-modification clinical trials in PD, … statistical analyses, and the
pre-defined trial length; (6) study … agitation and clinical progression of Alzheimer disease. Arch …

… review of longitudinal studies which measure Alzheimer's … used data from other cohort studies
(eg, Alzheimer's Disease … cases of Alzheimer's disease over the length of the clinical trial (…

… In the present study, we assess statistical power from using … clinical trial duration is based
on a review of recent clinical … statistical analysis, study design, and drafting of manuscript. …

… the design and conduct of future similar clinical trials. … to the anticipated duration of the
TOMMORROW trial. The … in the Statistical Analysis Plan. Details regarding sample size …

… these studies, several comprehensive reviews of anti-AD drug … This yielded important data
for further clinical trials involving … uncorrected, poorly designed clinical studies; and moreover, …

… of a systematic review and meta-analysis investigating the … We preferred intention-to-treat
analysis data to per-protocol data. … The mean treatment length was 25 weeks and ranged from …

… randomised clinical trials (RCTs) when intermediate sequential analyses … data extraction
We included placebo-controlled, double-blind, parallel-design RCTs with a minimum duration …

… review and suggest approaches for AD clinical trial design … overall clinical trial design with
utilized statistical measures that … As the duration, complexity, and cost of clinical trials increase…

… severe AD dementia) produce a statistically significant difference … A review of the literature
identifies several steps in drug … in trials of 6 months or more duration is indicative of a failed trial…

… FDA-regulated clinical trial phases as a function of their length, … The following review of
clinical trial data aims at being … of trial design begin with the designation of clinically meaningful …