The role of heme oxygenase-1 in hematopoietic system and its microenvironment

A Szade, K Szade, M Mahdi, A Józkowicz - Cellular and Molecular Life …, 2021 - Springer
… how HO-1 influences hematopoietic stem cells (HSC) self-… of HO-1 in endothelial cells and
mesenchymal stromal cells that … and cellular mechanisms by which HO-1 modulates innate …

Heme oxygenase-1 gene modified human placental mesenchymal stem cells promote placental angiogenesis and spiral artery remodeling by improving the balance …

D Wu, Y Liu, XX Liu, WF Liu, HR Shi, Y Zhang, L Zou… - Placenta, 2020 - Elsevier
… MSCs via enhanced pro-angiogenesis factor expression. Moreover, we engineered MSCs
by … them with the HO-1 gene to withstand ischemia and promote stem cell angiogenesis [15]. …

Identification of cyclins A1, E1 and vimentin as downstream targets of heme oxygenase-1 in vascular endothelial growth factor-mediated angiogenesis

A Bauer, H Mylroie, CC Thornton, D Calay… - Scientific reports, 2016 - nature.com
… or stromal cell-derived factor-1α (SDF-1α) led to translocation of nuclear factor E2-related
factor 2 (Nrf2) and induction of HO-1. … of Nrf2 activation for angiogenesis 24 . Meanwhile, the …

The diverse roles of heme oxygenase-1 in tumor progression

KN Luu Hoang, JE Anstee, JN Arnold - Frontiers in immunology, 2021 - frontiersin.org
… TAMs, which and are a prevalent stromal cell type in the TME, and are a major stromal
the biological effects of endogenous cell derived heme catabolites produced by HO-1-expressing …

Overexpression of heme oxygenase-1 in bone marrow stromal cells promotes microenvironment-mediated imatinib resistance in chronic myeloid leukemia

P Liu, D Ma, Z Yu, N Zhe, M Ren, P Wang, M Yu… - Biomedicine & …, 2017 - Elsevier
… In this context, the CXCL12 (also known as stromal cell-derived factor-1, SDF-1)/CXCR4 …
stem cells and tumor stem cells to bone marrow stromal cells, attracts tumor stem cells to homing…

Heme Oxygenase-1 as therapeutic target for diabetic foot ulcers

EC Leal, E Carvalho - International Journal of Molecular Sciences, 2022 - mdpi.com
… Moreover, bone marrow stem cells overexpressing HO-1 significantly promote angiogenesis
… This is consistent with studies showing that bone marrow cells derived from HO-1 deficient …

Role of heme oxygenase-1 and its reaction product, carbon monoxide, in manifestation of breast cancer stem cell-like properties: Notch-1 as a putative target

DH Kim, HJ Yoon, YN Cha, YJ Surh - Free Radical Research, 2018 - Taylor & Francis
… like cancer cells. In the present work, we investigated the role of heme oxygenase-1 (HO-1), …
It has been demonstrated that stem-like cells derived from mammospheres of various breast …

Bone marrow–derived mesenchymal stromal cells ameliorate severe acute pancreatitis in rats via hemeoxygenase-1–mediated anti-oxidant and anti-inflammatory …

Z Ma, G Song, D Zhao, D Liu, X Liu, Y Dai, Z He… - Cytotherapy, 2019 - Elsevier
… Interestingly, some studies indicated that NADPH oxidase p47phox and p67phox subunit
activity could be inhibited by heme oxygenase-1 (HO-1), thus reducing the production of ROS …

Role of stromal-derived factor-1 in mesenchymal stem cell paracrinemediated tissue repair

Q Luo, B Zhang, D Kuang… - Current stem cell research …, 2016 - ingentaconnect.com
… Furthermore, the expression of heme oxygenase-1 (HIF-1) … Time course of myocardial stromal
cellderived factor 1 … Mesenchymal stem cells overexpressing SDF-1 promote angiogenesis

[HTML][HTML] Mesenchymal stem cells modified with heme oxygenase-1 have enhanced paracrine function and attenuate lipopolysaccharide-induced inflammatory and …

X Chen, Y Zhang, W Wang, Z Liu, J Meng… - Cellular Physiology and …, 2018 - karger.com
… : Bone marrow-derived mesenchymal stem cell (BM-MSC) transplantation has therapeutic
effects on endothelial damage during acute lung injury (ALI). Heme oxygenase-1 (HO-1) can …