… (32) Ergoline is known to bind to orthosteric sites of all serotonin receptors and we concluded
that interactions involving this moiety should be crucial for ergotamine binding. In addition, …

… , RC; Xu, HE Structural basis for molecular recognition at serotonin receptors. Science, 2013,
340(… Low basicity as a characteristic for atypical ligands of serotonin receptor 5-HT2. Int. J. …

… progression of AD, the modulation of serotonin receptors the subtype 4 and 6 receptors (5-HT4R
and 5… the development of ligands for these serotonin receptors have emerged, and their …

… Serotonin is a neurotransmitter that activates intracellular signaling pathways through cell
surface receptors (9, 10). In addition, serotonin can covalently modify and thereby regulate the …

… The serotonin 4 receptor, 5-HT 4 R, represents one of seven different serotonin receptor
families and is implicated in a variety of physiological functions and their pathophysiological …

… domain of the receptor. The structural basis of such modulation of receptor function by
membrane … was recently shown in a cholesterol-bound crystal structure of the mGluR [137]. In the …

… 1a), which have been previously posited to form the structural basis of agonist and partial
agonist action 31 at β1AR and β2AR. D2R also contains TM5 serine residues (Supplementary …

… organic molecules. In terms of molecular recognition, a variety of different types of receptors
have … structures to both acyclic and cyclic small molecules [61]. Macrocyclic and semi-rigid …

… serotonin, 5HT3R antagonists (setrons), and recently, we have identified the structural basis
… We will present structures generated from cryo-electron microscopy imaging, validation of …

… serotonin in the human body [19]. Therefore, specific serotonin receptor subtypes that mediate
serotonin signaling can be used as therapeutic targets to regulate serotonin interactions. …