… In order to link PTKs to downstream signaling proteins and … site, making it available for
substrate recognition and turnover [91,92]. … connected to C-SH2 by an SH2-Kinase linker [74]. The …

… (residues 85–138); a short linker referred to as the connector SH3/2 (residues 139–152),
which links the SH3 domain to the SH2 domain (residues 153–237); and a linker (linker SH2–…

… tion of the crystal structure of the Abl kinase domain bound to … toward the kinase domain was
similar between Abl, Fes and … analyzed purified Abl SH2-KD using a gel filtration coupled to …

… solution structures of multidomain c-Abl kinase core proteins … bound to the Abl kinase domain
the structure becomes more … of Abl and Bcr-Abl proteins with modified SH2-kinase linkers …

… coupled with enhanced sampling simulations of multiple Abl … The Abl kinase has a modular
structure comprising the two … (FES) related to the A-loop partial closure in the different Abl …

… This work provides strong evidence for the SH2-kinase interface as a pharmacologically …
Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase …

… our discussion of Abl-family kinases on the structural features of … Interestingly, the Fes crystal
structure where this SH2-kinase … Rather, the connections between the allosteric networks in …

… on Btk kinase activation resembles the phenotype of structure-guided … in SH2-kinase
domain intramolecular interfaces in the Abl and Fes kinases 6,25 , we hypothesized Btk kinase …

… c-Abl due to the structural similarity between c-Abl and Src conserved kinase domain. Our
… ), followed by SH3 and SH2 domains, the SH2-kinase linker (Linker), the tyrosine kinase …

… Nous avon aid mon el ni B k SH2-kinase activée adopte une … pour d'autres tyrosine kinases,
telles que Abl, Fes et Csk. … Bruton in 1952, although the link to BTK alterations was only …