… of the role of nickel as the essential metal ion in urease for the enzymatic catalysis of urea,
a … In 1975, jack bean urease was demonstrated to require nickel for the catalysis, providing …

… with urease to facilitate the transfer of nickel ions in the urease … [18], the urease contains
three catalytic sites constituted by … The structural studies provided insights into how UreD, UreF …

… to tightly control the intracellular nickel ion quota in the cell. … in the picture of urease activation,
both the structural and … exploited by urease to efficiently regulate its catalytic mechanism …

… This reports a nickel-bridging fluoride ion replacing the hydroxide ion present in the resting
state of the enzyme and a urea molecule replacing W1, W2, and W3 in the active site cavity …

… structure and active site are surprisingly conserved among different species 2 . The active
site of urease contains two Ni 2+ ions, … 3, and as expected, the catalytic activity of JBU was …

… In this review, historical and structural features, kinetics aspects, activation of the … presence
of nickel ions in the active site of the jack bean urease (JBU), obligatory for its catalytic activity […

… Overall, the theoretical study provided insight into the … urease apoprotein can acquire
some activity with non-nickel … Thus, the inhibition of urease catalytic activity by heavy metals…

… structures of bacterial and plant ureases have been determined. The active site of urease
contains two nickel ions … aerogenes urease (PDB: 1FWJ)96 consists of three catalytic units. …

… Urease is a nickel (Ni) enzyme that is essential for the … pneumoniae urease contains three
catalytic units arranged … of the urease maturation pathway could provide insights into the …

… zinc ions similarly coordinated to the nickel centers in urease … , in the crystal structure of
the inhibited urease, no water … of the catalytic center is hindered, decreasing urease activity …