… lead to Env trimer disassembly, and our cryo-EM structure of F6-bound X18 UFO trimers
has captured an intermediate state along the path of such induced Env disassembly (Fig. 3a). …

… Advances in our structural understanding of the HIV-1 Env glycoprotein are complemented
by … Structure and immune recognition of trimeric pre-fusion HIV-1 Env. Nature 2014; 514: 455-…

… trimer stability. Our approach provides a means to produce prefusion-closed Env trimers from
diverse HIV-1 … Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase …

… of the Env trimer from the CRF01_AE T/F100 HIV-1 strain … T/F100 trimer may have undergone
some of the initial structural … These studies showed that the HIV-1 trimer is an intrinsically …

… Env. Escalating CD4 triggering led to the sequential adoption of different pre-fusion
conformational states of the Env trimer, … , the basis of much of our current knowledge of Env …

… HIV-1 envelope glycoprotein (Env) trimer is the sole viral antigen on the surface of the HIV-1
virion and is responsible for mediating HIV-1 … A soluble version of the Env trimer has been …

… on studies using structural biology to reveal and define HIV-1 Env sites of vulnerability; to
improve Env trimers, by creating more … Structure and immune recognition of trimeric pre-fusion …

… , the structure of a detergent-solubilized Env trimer without … structures of two full-length HIV-1
Env constructs purified in detergent have also been reported [27,28]. These trimer structures …

… Structural studies of the HIV-1 Env trimer or its gp120 subunit have revealed tantalizing … ,
glycosylated gp120 structures lack the interprotomer interactions of the pre-fusion closed state ( …

… HIV-1 trimer metastability because it is poised to elongate the HR1 helix during fusion and
is disordered in all but one crystal structure of the SOSIP trimer 35 and one cryo-EM structure …