… encoded by the current circulating influenza A viruses; thus, … a series of S31N inhibitors with
the general structure of … p7 ion channel, the HIV Vpu ion channel, M2 from the influenza virus…

… of activity of S31N inhibitors to S31N/V27A and S31N/L26I as … developed to inhibit the single
M2-S31N mutant with better … Solution NMR structure of WJ332 in complex with M2-S31N (…

… the first crystal structure of the S31N mutant of influenza M2. … aligned to inhibitor-bound
solution NMR S31N structure 2MUV (… -1-amine inhibitor from 2MUV in channel pore, with water …

… the drug-resistant mutations to the amantadine binding site in the … NMR structure [Citation14].
Albeit successful for V27A … a dual inhibitor that targets both the WT and the S31N mutant …

… inhibitor that targets the AM2 S31N channel. This led to the identification of the novel drug-resistant
mutation … , and the L26I mutation was postulated to change the local structure of the …

… Among a handful of drug-resistant mutants, M2-S31N is the … that M2-S31N inhibitors were
active against several influenza … different structures or have different dynamics than M2-S31N, …

… Structure-guided design of AM2-S31N inhibitors has led to a … -S31N inhibitors, compounds
1 and 2 were chosen for the … We examined the binding kinetics for drug-resistant mutations …

… known drug resistant M2 channels V27A, S31N, and swine flu. … group of tested M2 variants
were all still inhibited by drugs … structure [Protein Data Bank (PDB) entry 2L0J] was mutated to …

… inhibited amantadine-sensitive viruses by blocking the function of wild-type A/M2, but it did
not have the same effect on S31N mutant A/M2 in … among influenza viruses, slight structural …

… , we chose a representative M2-S31N inhibitor, compound 3, as … these drug-resistant mutants,
we expressed each mutant M2 … of influenza antivirals to combat drug-resistant viruses, we …